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http://dx.doi.org/10.1007/s11064-024-04149-1 | DOI Listing |
J Agric Food Chem
June 2025
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
The natural product α-santonin was first used as an anthelmintic agent for animals and human beings with remarkable therapeutic effects; however, there are fewer reports and applications on its structural optimization and derivatives in the field of agrochemicals. Here, we designed and synthesized a series of novel α-santonin-based oxazole derivatives, evaluated their insecticidal activities against common pests, including Walker, Sulzer, and Linnaeus, and preliminarily explored the insecticidal mechanism. It was found that exhibited the strongest GI activity against , with the final corrected mortality rate of 96.
View Article and Find Full Text PDFJ Neuroinflammation
May 2025
School of Public Health, Dalian Medical University, Dalian, 116044, China.
Front Mol Neurosci
March 2025
Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
[This corrects the article DOI: 10.3389/fnmol.2024.
View Article and Find Full Text PDFMetab Brain Dis
March 2025
Medicinal Plant Research Center, Department of Physiology, Faculty of Medicine, Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
J Neuroimmune Pharmacol
February 2025
Pharmacology and Toxicology Department, Faculty of Pharmacy, Menoufia University, Menoufia, 32951, Egypt.
Parkinson's disease (PD) is the main neurodegenerative disorder affecting motor activity, there are different pathophysiological pathways contributing to its development including oxidative stress, neuroinflammation, Lewy's bodies accumulation, and impaired autophagy. Vinpocetine is an herbal extract with antioxidant and anti-inflammatory activities that may counteract pathophysiologic neurodegeneration pathways. Moreover, Lactobacillus is a probiotic that can modulate the gut-brain axis and provide the body with the needed precursors of antioxidants and anti-inflammatory mediators.
View Article and Find Full Text PDF