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Nanoplastic-lipid interaction is vital to understanding the nanoscale mechanism of plastic adsorption and aggregation on a lipid membrane surface. However, a single-particle mechanistic picture of the nanoplastic transport process on a lipid surface remains unclear. Here, we report a salt-dependent non-Gaussian transport mechanism of polystyrene particles on a supported 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC) lipid bilayer surface. Particle stickiness on the POPC surface increases with salt concentration, where the particles stay longer at the surface and diffuse to shorter distances. Additionally, a non-Gaussian diffusion state dominates the transport process at high salt concentrations. Our current study provides insight into the transport mechanism of polystyrene (PS) particles on supported lipid membranes, which is essential to understanding fundamental questions regarding the adsorption mechanisms of nanoplastics on lipid surfaces.
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http://dx.doi.org/10.1021/acs.jpclett.4c00806 | DOI Listing |
Philos Trans A Math Phys Eng Sci
June 2025
Weizmann Institute of Science, Rehovot, Israel.
Deep generative models (DGMs) have been studied and developed primarily in the context of natural images and computer vision. This has spurred the development of (Bayesian) methods that use these generative models for inverse problems in image restoration, such as denoising, inpainting and super-resolution. In recent years, generative modelling for Bayesian inference on sensory data has also gained traction.
View Article and Find Full Text PDFGenet Epidemiol
July 2025
Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
For complex traits such as lung disease in Cystic Fibrosis (CF), Gene x Gene or Gene x Environment interactions can impact disease severity but these remain largely unknown. Unaccounted-for genetic interactions introduce a distributional shift in the quantitative trait across the genotypic groups. Joint location and scale tests, or full distributional differences across genotype groups can account for unknown genetic interactions and increase power for gene identification compared with the conventional association test.
View Article and Find Full Text PDFInt J Biol Macromol
June 2025
Department of Engineering and Architecture, Trieste University, via Valerio 6, I-34127 Trieste, Italy. Electronic address:
Polymeric hydrogels are paramount to outstanding applications in materials science, biology, medicine, pharmacy. Their similarity to living tissues is leveraged in clinical branches (oncology, cardiology, immunology, neurology, wound healing) for delivering a large range of drugs (encompassing DNA, RNA, protein molecules) and realizing in-vivo models of stimuli-responsive or controlled drug release. Rubber elasticity theory and the swollen network hypothesis are key for properly designing the geometric and mechanical features of hydrogels and polymer networks.
View Article and Find Full Text PDFPhys Rev Lett
April 2025
Université de Sherbrooke, Département de physique, Institut quantique, Sherbrooke, Québec J1K 2R1, Canada.
The statistics of electron transport in a quantum conductor is affected by fluctuations of its voltage bias. Here, we show experimentally how a third order correlation in the electromagnetic field arises from the noise of a tunnel junction in the microwave domain being modulated by the vacuum fluctuations generated by a resistor at ultralow temperature. This provides a way to measure the vacuum fluctuations experienced by the junction, not offset by the unavoidable noise added by the detection setup.
View Article and Find Full Text PDFAIChE J
February 2024
Department of Chemical Engineering, University of Rhode Island, Kingstown, Rhode Island, USA.
The ability of nanoparticles to penetrate and transport through soft tissues is essential to delivering therapeutics to treat diseases or signaling agents for advanced imaging and sensing. Nanoparticle transport in biological systems, however, is challenging to predict and control due to the physicochemical complexity of tissues and biological fluids. Here, we demonstrate that nanoparticles suspended in a novel class of soft matter-polymer-linked emulsions (PLEs)-exhibit characteristics essential for mimicking transport in biological systems, including subdiffusive dynamics, non-Gaussian displacement distributions, and decoupling of dynamics from material viscoelasticity.
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