Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with obesity and obstructive sleep apnea syndrome (OSA). Obesity and OSA may increase the risk of AF by affecting cardiovascular health.
Methods: The study used the Mendelian randomization (MR) approach, combined with two-sample and multivariable analyses, to assess the relationships between obesity, OSA, and AF. The study utilized GWAS data and applied various statistical methods for the analysis.
Results: The study found that obesity increased the risk of OSA, which in turn significantly increased the risk of AF. Through mediating MR analysis, it was found that OSA played a certain role in the causal relationship between obesity and AF, with about 6.4% of the risk of AF being mediated by OSA.
Conclusion: This study highlights the relationships among obesity, OSA, and AF, providing useful guidance for future clinical researches.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11066229 | PMC |
| http://dx.doi.org/10.3389/fcvm.2024.1406192 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-Term Outcomes of Liver Pathology Following a Sleeve Gastrectomy.
J Laparoendosc Adv Surg Tech A
September 2025
Department of Surgery, Veterans Affairs Medical Center, Washington, District of Columbia, USA.
The rising prevalence of obesity in the United States is paralleled by an increase in type II diabetes (T2D) and metabolic-associated steatotic liver disease. While lifestyle changes often do not afford sustainable weight loss, bariatric surgery, particularly sleeve gastrectomy (SG), offers a durable solution. This study investigates long-term outcomes in Veterans who underwent SG with concurrent liver biopsy.
View Article and Find Full Text PDFImpact of Obstructive Sleep Apnea on Outcomes After Anterior Cervical Discectomy and Fusion: A Propensity Matched Analysis.
Spine (Phila Pa 1976)
October 2025
Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, Philadelphia, PA.
Study Design: Retrospective cohort.
Objective: To evaluate the impact of having a history of obstructive sleep apnea (OSA) in patients undergoing anterior cervical discectomy and fusion (ACDF) on postoperative outcomes.
Background: With an aging population and rates of obesity increasing, comorbidities that influence patient safety are increasingly common.
Bariatric Surgery and Incident Development of Obesity-Related Comorbidities.
JAMA Netw Open
September 2025
Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Importance: As obesity rates rise in the US, managing associated metabolic comorbidities presents a growing burden to the health care system. While bariatric surgery has shown promise in mitigating established metabolic conditions, no large studies have quantified the risk of developing major obesity-related comorbidities after bariatric surgery.
Objective: To identify common metabolic phenotypes for patients eligible for bariatric surgery and to estimate crude and adjusted incidence rates of additional metabolic comorbidities associated with bariatric surgery compared with weight management program (WMP) alone.
Targeted Delivery of CNS-Specific Hesperidin as a Leptin Sensitizer for Treating Obesity-Associated Sleep-Disordered Breathing.
Adv Sci (Weinh)
September 2025
Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Obesity-associated obstructive sleep apnea (OSA) highlights the need for effective therapies. Hypothalamic endoplasmic reticulum (ER) stress contributes to leptin resistance in obesity. Although hesperidin (HE) modulates ER stress and oxidative pathways, its low bioavailability limits clinical use, its role in OSA is unknown.
View Article and Find Full Text PDFAssociation Between the Chinese Visceral Adiposity Index and Obstructive Sleep Apnoea in Hypertensive Patients with Normal-Weight: A Cross-Sectional Study.
Int J Gen Med
September 2025
Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, 830001, People's Republic of China.
Objective: Previous studies have mainly focused on the relationship between the Chinese Visceral Adiposity Index (CVAI) and obstructive sleep apnea (OSA) in general or overweight/obese populations. However, normal-weight hypertensive patients represent a clinically relevant yet understudied group, in whom OSA risk may be underestimated due to the absence of overt obesity. This study aimed to investigate the association between CVAI and OSA in normal-weight patients with hypertension, given the important role of visceral adiposity in the pathogenesis of OSA.
View Article and Find Full Text PDF