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Article Abstract
Background: Interaction of PD-1 protein (present on immune T-cell) with its ligand PD-L1 (over-expressed on cancerous cell) makes the cancerous cell survive and thrive. The association of PD-1/PD-L1 represents a classical protein-protein interaction (PPI), where receptor and ligand binding through a large flat surface. Blocking the PD-1/PDL-1 complex formation can restore the normal immune mechanism, thereby destroying cancerous cells. However, the PD-1/PDL1 interactions are only partially characterized.
Objective: We aim to comprehend the time-dependent behavior of PD-1 upon its binding with PD-L1.
Methods: The current work focuses on a molecular dynamics simulation (MDs) simulation study of and ligand bound PD-1.
Results: Our simulation reveals the flexible nature of the PD-1, both in and bound form. Moreover, the current study also differentiates the type of strong and weak interactions which could be targeted to overcome the complex formation.
Conclusion: The current article could provide a valuable structural insight about the target protein (PD-1) and its ligand (PD-L1) which could open new opportunities in developing small molecule inhibitors (SMIs) targeting either PD-1 or PD-L1.
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| http://dx.doi.org/10.2174/0113892037297012240408063250 | DOI Listing |
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