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(GBS), also known as , is a gram-negative, beta-hemolytic facultative anaerobe that causes neonatal pneumonia and sepsis. The neoplastic epithelial cells in adults, especially those of squamous origin, can show special adhesive properties toward GBS, which tends to reside within these tumors. There are some animal and human studies proving this association. Here, we present a 64-year-old female patient who had lung carcinoma of mixed adeno and squamous origin found to have persistent GBS every time the bronchoscopy was done for tumor ablation or cryotherapy. Subsequently, after starting her on chemo-radiotherapy, she also presented with multiple episodes of pneumonia caused by GBS and Moreover, many animal studies have shown the anti-tumor properties of GBS toxin that can prevent its metastasis and stop vascular growth surrounding the tumor. This property of GBS toxin can prove a blessing in disguise.
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http://dx.doi.org/10.7759/cureus.57377 | DOI Listing |
Cureus
August 2025
Department of Otolaryngology - Head and Neck Surgery, China Medical University Hospital, Taichung, TWN.
Synchronous malignancies involving the oropharynx and thyroid gland are rare. We report the case of a 52-year-old female diagnosed with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) with a concurrent, clinically occult papillary thyroid carcinoma (PTC). The patient initially presented with HPV-associated OPSCC and concerns for cervical lymphadenopathy, presumed to be linked to regional metastasis from the oropharyngeal primary.
View Article and Find Full Text PDFClin Anat
September 2025
Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand.
The postglenoid foramen (PGF) is a rarely reported anatomical variant of the temporal bone, with limited data on its morphology, prevalence, and clinical relevance, particularly in non-European populations. This study aimed to investigate the anatomy and frequency of foramina located on the squamous part of the temporal bone, including the PGF, and to propose a classification system based on their anatomical positions. A total of 117 human skulls (234 sides), including both dried and Thiel-embalmed specimens, were examined through gross observation, cadaveric dissection, and computed tomography (CT) in selected cases.
View Article and Find Full Text PDFFEBS Open Bio
September 2025
Unit of Biophysics and Bioengineering, Department of Biomedicine, University of Barcelona, Spain.
Non-small cell lung cancer (NSCLC) is the most common lung cancer type and one of the deadliest neoplasias worldwide. NSCLC is histologically classified into adenocarcinoma, squamous cell carcinoma, and other less frequent subtypes. Both subtypes and other solid tumors are increasingly regarded as abnormal organs, highlighting the critical role of the desmoplastic tumor stroma rich in cancer-associated fibroblasts (CAFs) in driving tumor progression and therapeutic resistance.
View Article and Find Full Text PDFCancer Lett
September 2025
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenbaum Cancer Center, University
Head and neck squamous cell carcinoma (HNSCC) originates in the epithelial lining of the oral cavity, pharynx, and larynx, with over 830,000 new cases diagnosed globally in 2020, making it the seventh most prevalent cancer. Despite treatment advances, high-grade HNSCCs remain associated with poor outcomes and a high risk of recurrence. Although Cancer Stem Cells (CSCs) are rare in HNSCC tumors, they are key drivers of tumor relapses, as they evade apoptosis and survive current therapies through enhanced DNA repair and quiescence.
View Article and Find Full Text PDFJ Vet Diagn Invest
September 2025
Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Spontaneous ejection of tissues from body orifices is rare in veterinary medicine. Here we underscore the diagnostic value of tissues spontaneously ejected from the nose or mouth of 21 dogs and submitted for histologic evaluation at 3 veterinary diagnostic institutions. Cases were retrospectively searched (2000-2024) from the Athens Veterinary Diagnostic Laboratory, Tifton Veterinary Diagnostic and Investigational Laboratory, and Antech Diagnostics web-based archive systems.
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