Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132991 | PMC |
| http://dx.doi.org/10.1038/s42255-023-00959-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of cumin and coriander seeds consumption on dyslipidemia, abdominal fat, body weight, and lipid profile in rat models.
Cell Mol Biol (Noisy-le-grand)
September 2025
Department of Health Sciences, University of York, York, U.K..
Dyslipidemia is considered a crucial risk factor for high risk of atherosclerosis and cardiovascular diseases. Cumin and coriander seeds are well-known flavoring agents that contain nutraceutical properties and appear to have beneficial health effects. A study was therefore conducted to investigate the effects of cumin and coriander seeds on body weight, abdominal fat and lipid profile in rats.
View Article and Find Full Text PDFMagnetic Resonance Imaging Demonstrates Differences in Brow and Upper Eyelid Fat and Muscle Layers Between East Asians and Caucasians.
Ophthalmic Plast Reconstr Surg
September 2025
Division of Orbital and Ophthalmic Plastic Surgery.
Purpose: To objectively quantify, in East Asians and Caucasians, the width and distribution of the retro-orbicularis oculi and frontalis fat (ROOF) pad, subcutaneous fat, and orbicularis oculi muscle (OOM) at the superior orbital rim margin as well as 5 mm superior and inferior to this point.
Methods: Thirty adults were studied by high-resolution, surface coil MRI. In the quasi-sagittal image through the globe center, the ROOF, subcutaneous fat, and OOM thickness were measured anterior to the orbital septum, at 3 points: at the superior orbital rim, and 5 mm superior, and 5 mm inferior to the rim.
Effects of Donor Cell Type on Developmental Competence of Canine-Porcine Interspecies Cloned Embryos.
Reprod Domest Anim
September 2025
National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
Canine somatic cell nuclear transfer (SCNT) is a powerful technology that can be used to clone beloved companion dogs, produce valuable working dogs, rescue endangered canine breeds, and create genetically engineered dogs. Nevertheless, the application of this technology is hindered by the low developmental efficiency of canine SCNT embryos. It has been shown that in pig and horse cloning using mesenchymal stem cells (MSCs), compared with fibroblasts, as donor cells can enhance the developmental potential of SCNT embryos.
View Article and Find Full Text PDFEffects of Brown Rice, Meal Replacements, and Anti-Obesity Drugs on Mitochondria in Obese Rats.
Diabetes Metab Syndr Obes
September 2025
School of Medical, Indigenous and Health, University of Wollongong, Wollongong, New South Wales, Australia.
Introduction: Obesity remains a critical global health challenge, intricately linked to poor dietary quality, gut microbiota dysbiosis, and mitochondrial dysfunction.
Purpose: This study aimed to investigate the comparative effects of brown rice, meal replacements, and thiazolidinediones on mitochondrial abundance and gut microbiota composition in a rat model of diet-induced obesity.
Methods And Materials: A total of twenty male Sprague Dawley rats were randomly assigned to five groups: control, high-fat high-fructose diet, and three intervention groups receiving the same obesogenic diet supplemented with brown rice, meal replacement, or thiazolidinediones for twelve weeks.
Mitochondrial membrane remodeling during heat acclimation in Mongolian gerbils.
Mar Life Sci Technol
August 2025
School of Life Sciences, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237 China.
Unlabelled: Mongolian gerbils had high ability to endure both high and cold temperatures. To study the mechanism of high ability for thermal adaptation, gerbils were acclimated to high temperature (30 °C) for 8 weeks, and were measured for metabolic features, body composition as well as mitochondrial content and activities. Lipidomic techniques were used to measure changes in mitochondrial membrane, including potential mitochondrial membrane remodeling during acute thermoregulation in gerbils.
View Article and Find Full Text PDF