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Object detection methods based on deep learning have been used in a variety of sectors including banking, healthcare, e-governance, and academia. In recent years, there has been a lot of attention paid to research endeavors made towards text detection and recognition from different scenesor images of unstructured document processing. The article's novelty lies in the detailed discussion and implementation of the various transfer learning-based different backbone architectures for printed text recognition. In this research article, the authors compared the ResNet50, ResNet50V2, ResNet152V2, Inception, Xception, and VGG19 backbone architectures with preprocessing techniques as data resizing, normalization, and noise removal on a standard OCR Kaggle dataset. Further, the top three backbone architectures selected based on the accuracy achieved and then hyper parameter tunning has been performed to achieve more accurate results. Xception performed well compared with the ResNet, Inception, VGG19, MobileNet architectures by achieving high evaluation scores with accuracy (98.90%) and min loss (0.19). As per existing research in this domain, until now, transfer learning-based backbone architectures that have been used on printed or handwritten data recognition are not well represented in literature. We split the total dataset into 80 percent for training and 20 percent for testing purpose and then into different backbone architecture models with the same number of epochs, and found that the Xception architecture achieved higher accuracy than the others. In addition, the ResNet50V2 model gave us higher accuracy (96.92%) than the ResNet152V2 model (96.34%).
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http://dx.doi.org/10.7717/peerj-cs.1769 | DOI Listing |
ACS Appl Mater Interfaces
September 2025
Department of Organic and Nano Engineering, and Human-Tech Convergence Program, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
Photomultiplication-type organic photodetectors (PM-type OPDs) have recently attracted attention. However, the development of polymer donors specifically tailored for this architecture has rarely been reported. In this study, we synthesized benzobisoxazole-based polymer donors incorporating alkylated π-spacers that simultaneously enhance photocurrent density () and suppress dark current density (), leading to high responsivity () and specific detectivity (*).
View Article and Find Full Text PDFJ Mater Chem B
September 2025
Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum - Università di Bologna, Via Piero Gobetti, 85, Bologna 40129, Italy.
Donor-acceptor-donor (D-A-D) thiophene-based compounds, characterized by thiophene as a donor unit and benzothiadiazole (Bz) as an acceptor, represent an emerging class of theranostic agents for imaging and photodynamic therapy. Here, we expand this class of molecules by strategically varying the position of the electron-accepting unit within the oligothiophene (OT) backbone structure, realizing a series of different push-pull architectures (A-D, D-A-D, and D-A). This rational design allows for precise modulation of key photophysical parameters, including absorption and emission spectra, molar absorption coefficient, charge separation, and frontier molecular orbitals.
View Article and Find Full Text PDFBackground: Intervertebral disc degeneration (IDD) is a prevalent spinal condition frequently associated with pain and motor impairment, imposing a substantial burden on quality of life. Despite extensive investigations into the genetic predisposition to IDD, the precise pathogenic genes and molecular pathways involved remain inadequately characterized, underscoring the need for continued research to clarify its genetic underpinnings.
Methods: This study leveraged IDD data from the FinnGen R12 cohort and integrated expression quantitative trait loci data across 49 tissues from the Genotype-Tissue Expression version 8 database to perform a cross-tissue transcriptome-wide association study (TWAS).
IEEE Trans Comput Biol Bioinform
September 2025
Deciphering the three-dimensional structure of proteins remains a grand challenge in biology and medicine, as it holds the key to understanding their biological functions and facilitating drug discovery. In this paper, we introduce DECIPHER (Deep Encoding of Cellular Interactions and Protein HiErarchical Representation), a novel deep graph learning framework for protein structure prediction. By representing proteins as graphs, where residues and atoms serve as nodes and their interactions form edges, we capture the intricate spatial relationships within these complex biomolecules.
View Article and Find Full Text PDFBrief Funct Genomics
January 2025
School of Mathematics and Statistics, Henan University of Science and Technology, No. 263 Kaiyuan Avenue, Luolong District, Luoyang, Henan 471000, China.
Background: Comorbidities and genetic correlations between gastrointestinal tract diseases and psychiatric disorders have been widely reported, but the underlying intrinsic link between Alzheimer's disease (AD) and inflammatory bowel disease (IBD) is not adequately understood.
Methods: To identify pathogenic cell types of AD and IBD and explore their shared genetic architecture, we developed Pathogenic Cell types and shared Genetic Loci (PCGL) framework, which studied AD and IBD and its two subtypes of ulcerative colitis (UC) and Crohn's disease (CD).
Results: We found that monocytes and CD8 T cells were the enriched pathogenic cell types of AD and IBDs, respectively.