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http://dx.doi.org/10.1097/CORR.0000000000003085 | DOI Listing |
Purpose: WU-KONG1B (ClinicalTrials.gov identifier: NCT03974022) is a multinational phase II, dose-randomized study to assess the antitumor efficacy of sunvozertinib in pretreated patients with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor () exon 20 insertion mutations (exon20ins).
Methods: Eligible patients with advanced-stage exon20ins NSCLC were randomly assigned by 1:1 ratio to receive sunvozertinib 200 mg or 300 mg once daily (200 and 300 mg-rand cohorts).
Clin Immunol
August 2025
Host-Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Electronic address:
Staphylococcus aureus nasal colonisation is commonplace among healthy individuals, yet the immune mechanisms enabling bacterial persistence remain unclear. S. aureus drives local immunosuppression during nasal colonisation to facilitate persistence.
View Article and Find Full Text PDFBackground: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital with COVID-19.
Methods: Patients admitted with COVID-19 pneumonia to 107 UK hospitals were randomly assigned (1:1) to either usual care alone or usual care plus a single 1 g infusion of sotrovimab, using web-based unstratified randomisation.
Front Oncol
August 2025
Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, Macau SAR, China.
Objective: This study examines the trends in thyroid cancer incidence and mortality and explores their relationship with national development levels.
Methods: Data on thyroid cancer from 47 countries were sourced from the Global Burden of Disease 2021 study, covering the years 1990-2021. National development was measured using the Human Development Index (HDI), Social Progress Imperative (SPI), Nutrition and Medical Care (NMC), the Density of Doctors per 100,000 population (DOD), and Personal Healthcare Spending (PHS).
Clin Orthop Relat Res
June 2025
Professor, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.