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Oxidative stress mediates cardiac electrophysiological injury in inhalation exposure to flavored vaping products.
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Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, United States. Electronic address:
Background: Electronic nicotine delivery systems (ENDS) utilize "E-liquids" in order to generate "E-vapor", an inhalable aerosolized mixture containing nicotine and flavors. Flavored ENDS are very popular among teens who vape, however, the possible cardiac electrophysiological harm of inhalation exposure to flavored ENDS are not fully understood.
Objective: To test if inhalation exposure to flavoring carbonyls in e-liquids compromises mitochondrial integrity, increases oxidative stress, and leads to cardiac electrophysiological toxicity.
Inhaler identification: evaluating a potential screening method for adherence in chronic respiratory disease management.
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. Departamento de Pneumologia do Hospital Infante D. Pedro, Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal.
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UGT2B7-mediated drug-drug interaction between cannabinoids and hydromorphone.
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Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington; Division of Molecular Biosciences, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York
Hydromorphone is a highly potent opioid used to treat severe chronic pain. It is metabolized primarily by UDP-glucuronosyltransferase (UGT)2B7 to form the inactive hydromorphone-3-glucuronide. Given that previous studies have shown that the major cannabinoids, Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), inhibit several UGT enzymes, the objective of the present study was to determine the inhibitory potential of major cannabinoids and their metabolites on UGT-mediated hydromorphone metabolism.
View Article and Find Full Text PDFProspective randomised controlled trial comparing PLLA and PLDLA/HA/β-TCP interference screws in anterior cruciate ligament reconstruction: CT scans, MRI and clinical outcomes.
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Department of Orthopaedics and Trauma Surgery, Medical University of Innsbruck, Innsbruck, Austria.
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