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Different grasping gestures result in the change of muscular activity of the forearm muscles. Similarly, the muscular activity changes with a change in grip force while grasping the object. This change in muscular activity, measured by a technique called Electromyography (EMG) is used in the upper limb bionic devices to select the grasping gesture. Previous research studies have shown gesture classification using pattern recognition control schemes. However, the use of EMG signals for force manipulation is less focused, especially during precision grasping. In this study, an early predictive control scheme is designed for the efficient determination of grip force using EMG signals from forearm muscles and digit force signals. The optimal pattern recognition (PR) control schemes are investigated using three different inputs of two signals: EMG signals, digit force signals and a combination of EMG and digit force signals. The features extracted from EMG signals included Slope Sign Change, Willison Amplitude, Auto Regressive Coefficient and Waveform Length. The classifiers used to predict force levels are Random Forest, Gradient Boosting, Linear Discriminant Analysis, Support Vector Machines, k-nearest Neighbors and Decision Tree. The two-fold objectives of early prediction and high classification accuracy of grip force level were obtained using EMG signals and digit force signals as inputs and Random Forest as a classifier. The earliest prediction was possible at 1000 ms from the onset of the gripping of the object with a mean classification accuracy of 90 % for different grasping gestures. Using this approach to study, an early prediction will result in the determination of force level before the object is lifted from the surface. This approach will also result in better biomimetic regulation of the grip force during precision grasp, especially for a population facing vision deficiency.
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http://dx.doi.org/10.1016/j.heliyon.2024.e28716 | DOI Listing |
Proc Biol Sci
August 2025
Biological Sciences, The George Washington University, Washington, DC 20052, USA.
Many salamanders climb extensively but lack morphological adaptations, such as claws or adhesive toe pads, found in other climbing tetrapods. Here, we compared climbers and non-climbers from the salamander genera and to evaluate potential morphological adaptations for climbing across multiple levels of biological organization. We integrated body shape morphometrics, allometry of the autopods (manus and pes), mechanical advantage of the digits and comparisons of epithelial microstructures.
View Article and Find Full Text PDFEarly Hum Dev
August 2025
Institute of Psychology, University of Wrocław, Poland.
Background: The relationship between the second (2D) and fourth finger (4D) of the hand (2D:4D) is considered to be a proxy indicator of prenatal- testosterone (PT) and estrogen (PE) exposure in the first trimester of pregnancy. A lower 2D:4D indicates relatively higher PT exposure and vice versa. The 2D:4D is generally higher in women than in men.
View Article and Find Full Text PDFChemMedChem
August 2025
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 160 00, Prague 6, Czech Republic.
Hypoxanthine-guanine-(xanthine) phosphoribosyltransferase [HG(X)PRT] is an excellent target for the development of new drugs to treat parasitic and bacterial infections as well as MYC-dependent triple-negative breast cancer. Inhibitors include compounds that mimic the transition state of the catalytic reaction and analogs of the two products of the reaction, the nucleoside monophosphates and pyrophosphate. One type of chemistry explored here is the design of purine-based C1'-branched acyclic nucleoside phosphonates bearing diverse structural attachments (secondary linkers) on the C1' atom.
View Article and Find Full Text PDFLancet Digit Health
August 2025
Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:
Generative artificial intelligence has emerged as a transformative force in medical imaging since 2022, enabling the creation of derivative synthetic datasets that closely resemble real-world data. This Viewpoint examines key aspects of synthetic data, focusing on its advancements, applications, and challenges in medical imaging. Various generative artificial intelligence image generation paradigms, such as physics-informed and statistical models, and their potential to augment and diversify medical research resources are explored.
View Article and Find Full Text PDFDigit Health
August 2025
College of Nursing, Seoul National University, Seoul, Republic of Korea.
Background: Undergraduate students are particularly vulnerable to mental health problems due to academic pressure, financial concerns, and interpersonal stressors. Nature-based virtual reality (VR) technologies, which replicate natural settings, may offer psychological benefits by compensating for limited access to real-world natural environments in urban contexts.
Purpose: This study aimed to evaluate the effectiveness of a nature-based VR relaxation program in improving mental health and sleep outcomes among Korean undergraduate students.