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Mental health conversational agents (a.k.a. chatbots) are widely studied for their potential to offer accessible support to those experiencing mental health challenges. Previous surveys on the topic primarily consider papers published in either computer science or medicine, leading to a divide in understanding and hindering the sharing of beneficial knowledge between both domains. To bridge this gap, we conduct a comprehensive literature review using the PRISMA framework, reviewing 534 papers published in both computer science and medicine. Our systematic review reveals 136 key papers on building mental health-related conversational agents with diverse characteristics of modeling and experimental design techniques. We find that computer science papers focus on LLM techniques and evaluating response quality using automated metrics with little attention to the application while medical papers use rule-based conversational agents and outcome metrics to measure the health outcomes of participants. Based on our findings on transparency, ethics, and cultural heterogeneity in this review, we provide a few recommendations to help bridge the disciplinary divide and enable the cross-disciplinary development of mental health conversational agents.
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http://dx.doi.org/10.18653/v1/2023.emnlp-main.698 | DOI Listing |
Ren Fail
December 2025
Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Large language models (LLMs) represent a transformative advance in artificial intelligence, with growing potential to impact chronic kidney disease (CKD) management. CKD is a complex, highly prevalent condition requiring multifaceted care and substantial patient engagement. Recent developments in LLMs-including conversational AI, multimodal integration, and autonomous agents-offer novel opportunities to enhance patient education, streamline clinical documentation, and support decision-making across nephrology practice.
View Article and Find Full Text PDFClin Pediatr (Phila)
September 2025
Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
The adolescent mental health crisis is compounded by a shortage of mental health services, which mobile health apps may alleviate. We assessed the feasibility and acceptability of the Wysa app (a commercially available app containing cognitive behavioral therapy-based digital modules and an artificial intelligence-based conversational agent) among 13- to 18-year-old adolescents recruited from a primary care clinic in New York City and online from March to June 2022. We assessed adolescent engagement in the Wysa app over a 3-week period.
View Article and Find Full Text PDFAppl Psychol Health Well Being
October 2025
State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Background: Young adults face emotional problems in their daily lives. Considering that youth are prevalent among mobile internet users, it would be helpful if functions that can intervene in young people's depression and anxiety can be designed based on short video apps. Large language model (LLM)-based AI conversational agents based on short video apps may play an important role in intervening in young adults' negative emotions.
View Article and Find Full Text PDFPLOS Glob Public Health
September 2025
Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
The global population of older adults is growing. Older adults are more vulnerable to infectious diseases compared to younger adults. Vaccines are available to protect older adults against several infectious diseases, yet their uptake remains sub-optimal.
View Article and Find Full Text PDFBiomedicines
July 2025
Department of Integrative Translational Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
The RTK-RAS signaling cascade is a central axis in colorectal cancer (CRC) pathogenesis, governing cellular proliferation, survival, and therapeutic resistance. Somatic alterations in key pathway genes-including KRAS, NRAS, BRAF, and EGFR-are pivotal to clinical decision-making in precision oncology. However, the integration of these genomic events with clinical and demographic data remains hindered by fragmented resources and a lack of accessible analytical frameworks.
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