Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Among the 3 primary mutations of Leber's hereditary optic neuropathy (LHON), the incidence of LHON with a mutation at nucleotide position 3460 is the lowest in Asians. Therefore, information about the clinical manifestations of LHON mutations in Asians with the 3460 mutation is limited.
Objective: To determine the clinical manifestations including visual prognosis of Asians with the LHON 3460 mutation.
Methods: We performed a retrospective study of 5 Korean LHON patients with the 3460 mutation.
Results: All patients were male, and the age of onset for visual impairment varied from 17 to 35 years, with an average of 25.4 ± 7.16 years. Among the 10 affected eyes, only 1 eye of 1 patient showed visual improvement to 20/50 at 2 years after onset. The remaining patients had a visual acuity of worse than 20/200.
Conclusion: The visual prognosis of Korean patients with the LHON 3460 mutation was generally poor. Further studies regarding Asian patients with the LHON 3460 mutation are necessary.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcjo.2024.03.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Imaging characteristics, surgical efficacy and treatment strategies for Type IIIa atlantoaxial rotatory dislocation: a retrospective comparative study with Type III.
Eur J Orthop Surg Traumatol
September 2025
Department of Orthopedics, Shanghai Changzheng Hospital, Shanghai, China.
Purpose: To investigate the images and treatment differences for Type IIIa atlantoaxial rotary dislocation (AARD) by comparing the imaging characteristics of patients with Type III and Type IIIa AARD.
Methods: The present study retrospectively analyzed a cohort of 35 patients who underwent posterior C1-C2 intra-articular fusion due to AARD from our hospital database. Among them, 23 patients were diagnosed with Type III AARD, while the remaining 12 patients were diagnosed with Type IIIa AARD.
DigiNet: Optimizing personalized care for patients with stage IV non-small cell lung cancer (NSCLC) through a digitally connected provider network-analysis plan of a prospective multicenter cohort trial.
J Cancer Res Clin Oncol
September 2025
Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany.
Purpose: The German sector-based healthcare system poses a major challenge to continuous patient monitoring and long-term follow-up, both essential for generating high-quality, longitudinal real-world data. The national Network for Genomic Medicine (nNGM) bridges the inpatient and outpatient care sectors to provide comprehensive molecular diagnostics and personalized treatment for non-small cell lung cancer (NSCLC) patients in Germany. Building on the established nNGM infrastructure, the DigiNet study aims to evaluate the impact of digitally integrated, personalized care on overall survival (OS) and the optimization of treatment pathways, compared to routine care.
View Article and Find Full Text PDF[Clinical and laboratory aspects of ultrasound treatment for chronic wounds].
Khirurgiia (Mosk)
September 2025
Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus.
Objective: To evaluate clinical and laboratory effectiveness of ultrasound treatment for purulent wounds.
Material And Methods: The study enrolled 46 patients with purulent wounds divided into the main group (23 patients, ultrasonic treatment) and the control group (23 patients, traditional treatment). We assessed treatment effectiveness considering visual data, quality of granulation tissue, wound defect area and marginal epithelialization, complete blood count and C-reactive protein.
Efficacy of Correcting Different Types of Astigmatism With Small Incision Lenticule Extraction: A Prospective Contralateral Eye Study.
J Refract Surg
September 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Purpose: To evaluate axis-dependent visual and refractive outcomes of small incision lenticule extraction (SMILE) in patients with interocular astigmatic axis discordance.
Methods: Seventy-five patients (150 eyes) with interocular astigmatic axis discordance were included in the study. Based on interocular axis combinations, patients were stratified into three cohorts: with-the-rule (WTR)/against-the-rule (ATR) (n = 19), WTR/oblique astigmatism (OA) (n = 39), and ATR/OA (n = 17).
Effects of therapeutic exercise in patients with internal derangement of the temporomandibular joint: A prospective study.
Medicine (Baltimore)
September 2025
Department of Prosthodontics, Faculty of Dentistry, Van Lang University, Ho Chi Minh City, Vietnam.
This study examines the symptomatic and clinical features and variations in characteristics, such as angle and length of the condylar path in the sagittal plane during protrusion movement, in internal derangement patients treated with exercise therapy. Patients were selected and classified using the diagnostic criteria for temporomandibular disorders (DC/TMD) axis I. The therapeutic exercise program consisted of lateral jaw movements performed daily, with gradual progression to a target of 50 repetitions per day.
View Article and Find Full Text PDF