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Introduction: Problem gambling (PBG) is more common in people with mental health disorders, including substance use, bipolar, and personality disorders, than in the general population. Although individuals with psychotic disorders might be expected to be more vulnerable to PBG, fewer studies have focused on this comorbidity. The aim of this review was to estimate the prevalence of PBG in people with psychotic disorders.
Methods: Medline (Ovid), EMBASE, PsycINFO (Ovid), CINAHL, CENTRAL, Web of science, and ProQuest were searched on November 1, 2023, without language restrictions. Observational and experimental studies including individuals with psychotic disorders and reporting the prevalence of PBG were included. Risk of bias was assessed using the Joanna Briggs Institute critical appraisal for systematic reviews of prevalence data. The pooled prevalence of PBG was calculated using a fixed effects generalized linear mixed model and presented through forest plots.
Results: Of 1271 records screened, 12 studies (n = 3443) were included. The overall prevalence of PBG was 8.7% (95% CI = 7.8%-9.7%, I = 69%). A lower prevalence was found in studies with a low risk of bias (5.6%; 95% CI = 4.4%-7.0%) compared with studies with a moderate risk of bias (10.4%; 95% CI = 9.2%-11.7%). Different methods used to assess PBG also contributed to the heterogeneity found.
Conclusion: This meta-analysis found substantial heterogeneity, partly due to the risk of bias of the included studies and a lack of uniformity in PBG assessment. Although more research is needed to identify those at increased risk for PBG, its relatively high prevalence warrants routine screening for gambling in clinical practice.
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http://dx.doi.org/10.1111/acps.13686 | DOI Listing |
Nat Med
September 2025
Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
Microbiologyopen
August 2025
Patho-Biocatalysis Group (PBG), Department of Biochemistry and Biological Sciences, University of Fort Hare, Alice, South Africa.
Antimicrobial resistance (AMR) poses a critical global health threat, with Klebsiella pneumoniae emerging as a high-priority pathogen due to escalating resistance rates. This systematic review and meta-analysis evaluated the AMR profiles of K. pneumoniae isolates from South Africa, a resource-limited setting where AMR burdens remain understudied.
View Article and Find Full Text PDFHealthcare (Basel)
May 2025
Unit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
Multiple sclerosis (MS) is often associated with comorbidities that affect clinical outcomes. Data on comorbidities can be sourced from self-reports, medical records, and administrative databases. The gold standard for collecting such data is prospective clinical collection, as in clinical trials, but this is not feasible in large epidemiological studies.
View Article and Find Full Text PDFLiver Int
July 2025
Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Background And Aims: This study aimed to characterise symptoms and assess the prevalence of elevated urine porphyrin precursors in first-degree relatives of acute hepatic porphyria (AHP) patients who have never experienced acute attacks and had no previous AHP genetic or biochemical testing.
Methods: 149 first-degree relatives of confirmed AHP patients, previously unscreened for the family mutation, were recruited. All underwent genetic analysis, with 143 completing a study questionnaire and 118 undergoing urine analysis for delta aminolevulinic acid (ALA) and porphobilinogen (PBG).
Narra J
April 2025
Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Studies have associated advanced glycation end-products (AGEs) and the polymorphism of the AGEs receptor () gene with clinical disorders, such as diabetes, in certain ethnic groups. However, its association with type 1 diabetes mellitus (T1DM) in Egyptians has not yet been explored. The aim of this study was to investigate the association between the gene polymorphism rs1800625 and T1DM susceptibility in Egyptians.
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