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DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome is a rare, life-threatening, hypersensitivity reaction. The prolonged course and non-specific symptoms of the condition make diagnosis challenging. We present a case of DRESS syndrome that was misdiagnosed as urticaria. Investigations revealed deranged liver and kidney functions and abnormal blood count. The presented case emphasizes the need to have a high suspicion for DRESS syndrome in patients who present with jaundice, generalized rash, acute renal failure, and acute liver failure.
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http://dx.doi.org/10.7759/cureus.55355 | DOI Listing |
Macromol Rapid Commun
September 2025
Key Laboratory of Textile Science & Technology, College of Textiles, Ministry of Education, Donghua University, Shanghai, China.
Persistent bacterial infections remain a major challenge in wound management. Although drug-loaded wound dressings have gained increasing attention, their therapeutic efficacy is often hindered by uncontrolled drug release and a lack of electrical signal responsiveness. Herein, an antibacterial dressing (CCS-PC) with electroactivity and stimulus-responsive drug release properties was fabricated via electro-assembly, wherein chitosan and ciprofloxacin hydrochloride (CIP) were co-deposited onto polypyrrole (PPy)-coated gauze.
View Article and Find Full Text PDFCureus
August 2025
Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Tsu, JPN.
Conversion surgery is increasingly used for initially unresectable esophageal cancer patients responding to induction therapy. The integration of immune checkpoint inhibitors (ICIs) into standard chemotherapy regimens is expected to increase the number of patients undergoing this approach. However, ICIs can cause immune-related adverse events (irAEs), which are often difficult to diagnose in the postoperative setting.
View Article and Find Full Text PDFThe emergence of drug-resistant bacteria due to excessive antibiotic use has drawn increasing attention to inorganic nanoparticles for their broad-spectrum antibacterial properties. Here, a "green" strategy for the simultaneous in situ synthesis of silver nanoparticles (AgNPs) during the photocrosslinking process of casein hydrogels is described. The in situ photoactivated biomineralization of AgNPs provides noticeable stability and antibacterial activity, with high photothermal effect during a sequential near-infrared laser activation.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Burns, Plastic Surgery and Cosmetology, Chongqing University Fuling Hospital, Chongqing University, Chongqing, China.
Diabetic foot ulcers represent a significant complication of diabetes mellitus, presenting substantial challenges due to their intricate pathogenesis, which encompasses neuropathy, vasculopathy, chronic inflammation, and biofilm-associated infections. Despite considerable advancements in Western medical interventions, including surgical debridement, skin grafting, negative pressure wound therapy, and innovative dressings, these ulcers remain a leading cause of amputation and contribute to a substantial socioeconomic burden. Traditional Chinese medicine (TCM) has emerged as a promising adjunctive therapy, offering multi-targeted mechanisms that address oxidative stress, chronic inflammation, angiogenesis, and microbial resistance associated with diabetic foot ulcers.
View Article and Find Full Text PDFCurr Drug Deliv
August 2025
Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India.
Introduction: Burn wounds are painful injuries that demand immediate and effective management. Conventional wound care solutions often have limitations, such as discomfort during application or removal and potential damage to healing tissue. Therefore, developing novel wound dressings that support biological processes and promote wound healing is highly beneficial.
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