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http://dx.doi.org/10.1016/j.hrthm.2024.03.1763 | DOI Listing |
Electroporation is a promising technology utilizing electrical pulses for macromolecule delivery and soft-tissue ablation, with applications that include next-generation prophylactics and the treatment of genetic diseases such as cancer. This study demonstrates a high-throughput capable 3D tissue culture model for quantification of the reversible and irreversible electroporation thresholds for a given electroporation protocol. By using a non-uniform electric field and analyzing the spatial distribution of transfected cells, both reversible and irreversible thresholds can be identified within a single sample, increasing the efficiency at which electroporation protocols can be characterized, especially for in vivo translation.
View Article and Find Full Text PDFKardiol Pol
September 2025
Department of Cardiology, Stefan Cardinal Wyszynski Province Specialist Hospital, Lublin, Poland.
Eur Heart J Case Rep
September 2025
Clinical Electrophysiology, St. Joseph's Heart Rhythm Center, Anny Jagiellonki 17, 35-623 Rzeszów, Poland.
Background: Premature ventricular contractions (PVCs) originating from the infundibular region of the right ventricular outflow tract (RVOT) may be challenging to ablate due to thin myocardial wall and proximity to the coronary arteries in this region. In such anatomically sensitive regions, the use of radiofrequency (RF) energy may carry a risk of collateral injury or prove ineffective. We present a case report describing successful ablation of infundibular PVCs using pulsed field ablation (PFA).
View Article and Find Full Text PDFFront Physiol
August 2025
Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.
Background: Pulsed electric field ablation (PFA) techniques for treating cardiac arrhythmias have attracted considerable interest. For example, atrial fibrillation can be effectively treated by pulmonary vein isolation using PFA. However, some arrhythmias originate deep within the myocardium, making them difficult to reach with conventional ablation methods.
View Article and Find Full Text PDFTherapeutic treatment of lung nodules by ablation is a new field. Even though not considered standard of care, lung nodule ablation can be appropriate for select cases. Even though ablation is a safe and well-tolerated procedure, bleeding is a potential complication.
View Article and Find Full Text PDF