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The Antarctic Circumpolar Current (ACC) represents the world's largest ocean-current system and affects global ocean circulation, climate and Antarctic ice-sheet stability. Today, ACC dynamics are controlled by atmospheric forcing, oceanic density gradients and eddy activity. Whereas palaeoceanographic reconstructions exhibit regional heterogeneity in ACC position and strength over Pleistocene glacial-interglacial cycles, the long-term evolution of the ACC is poorly known. Here we document changes in ACC strength from sediment cores in the Pacific Southern Ocean. We find no linear long-term trend in ACC flow since 5.3 million years ago (Ma), in contrast to global cooling and increasing global ice volume. Instead, we observe a reversal on a million-year timescale, from increasing ACC strength during Pliocene global cooling to a subsequent decrease with further Early Pleistocene cooling. This shift in the ACC regime coincided with a Southern Ocean reconfiguration that altered the sensitivity of the ACC to atmospheric and oceanic forcings. We find ACC strength changes to be closely linked to 400,000-year eccentricity cycles, probably originating from modulation of precessional changes in the South Pacific jet stream linked to tropical Pacific temperature variability. A persistent link between weaker ACC flow, equatorward-shifted opal deposition and reduced atmospheric CO during glacial periods first emerged during the Mid-Pleistocene Transition (MPT). The strongest ACC flow occurred during warmer-than-present intervals of the Plio-Pleistocene, providing evidence of potentially increasing ACC flow with future climate warming.
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http://dx.doi.org/10.1038/s41586-024-07143-3 | DOI Listing |
Int J Nanomedicine
September 2025
Discipline of Pharmacology and Therapeutics, School of Medicine, University of Galway, Galway, Ireland.
Introduction: Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis, limited treatment options, and high recurrence rates. Surgery and mitotane-based chemotherapy remain the standard of care, and new treatment strategies are needed. Iron oxide nanoparticles (IONPs) offer promise as theranostic agents due to their modifiability for selective uptake and imaging.
View Article and Find Full Text PDFAcute Crit Care
August 2025
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Background: Arterial pH reflects both metabolic and respiratory distress in cardiac arrest and has prognostic implications. However, it was excluded from the 2024 update of the Utstein out-of-hospital cardiac arrest (OHCA) registry template. We investigated the rationale for including arterial pH into models predicting clinical outcomes.
View Article and Find Full Text PDFAcc Chem Res
August 2025
School of Chemical Engineering & Technology, Key Laboratory for Green Chemical Technology of Ministry of Education, Tianjin University, Collaborative Innovation Center for Chemical Science & Engineering, Tianjin 300072, China.
ConspectusAchieving carbon neutrality requires the development of robust carbon capture, utilization, and storage (CCUS) technologies. Among the various carbon utilization pathways, the electrochemical carbon dioxide (CO) reduction reaction (COR) presents a compelling approach, enabling the direct conversion of CO and water into valuable fuels and chemical feedstocks using renewable electricity. While recent breakthroughs in mechanistic insights, catalyst materials, and reactor designs have been achieved, significant challenges remain in translating promising lab-scale results into techno-economically viable technologies.
View Article and Find Full Text PDFCatheter Cardiovasc Interv
August 2025
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Background: Limited data exist on outcomes in patients with prior coronary artery bypass grafting (CABG) who, after bypass graft failure, undergo complex percutaneous coronary intervention (PCI) of the corresponding native vessel.
Aims: To compare outcomes of complex native vessel PCI in patients with and without prior CABG.
Methods: We retrospectively analyzed patients who underwent PCI of native vessels with complex lesions (calcified and ACC/AHA Type B2/C) at our catheterization laboratory between January 2012 and February 2020.
Tissue Cell
July 2025
Department of Thoracic Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264099, China. Electronic address:
Purpose: The purpose of this study was to investigate the biological role of immortalization-upregulated protein (IMUP) in lung cancer.
Methods: Through bioinformatics analysis, IMUP expression in lung cancer tissues, overall survival (OS) of patients with lung cancer, and the biological pathways related to IMUP were analyzed. IMUP expression was assessed utilizing immunohistochemistry staining, RT-qPCR, and western blot.