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Article Abstract
A migratory insertion of carbenes into distal γ-C(sp)-H bonds of aliphatic amines has been successfully developed. The synergistic interplay among a palladium catalyst, picolinamide directing group, a carefully selected base additive, and an essential ligand proved crucial in achieving high yields. These findings hold significant value for advancing the exploration of regioselective carbene insertions into nonactivated C(sp)-H bonds.
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| http://dx.doi.org/10.1021/acs.orglett.4c00038 | DOI Listing |
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