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There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954630 | PMC |
http://dx.doi.org/10.1038/s41522-024-00500-0 | DOI Listing |
JCO Glob Oncol
May 2025
Department of Obstetrics and Gynaecology, Stanford University School of Medicine, Stanford, CA.
Purpose: Expanding high-risk human papillomavirus (HPV) vaccine coverage in resource-constrained settings is critical to bridging the cervical cancer gap and achieving the global action plan for elimination. Mobile health (mHealth) technology via short message services (SMS) has the potential to improve HPV vaccination uptake. The mHealth-HPVac study evaluated the effectiveness of mHealth interventions in increasing HPV vaccine uptake among mothers of unvaccinated girls aged 9-14 years in Lagos, Nigeria.
View Article and Find Full Text PDFSex Transm Dis
September 2025
University of Illinois at Chicago School of Public Health, 1603 W. Taylor St., Chicago, IL, 60612.
Background: Human papillomavirus (HPV) is a leading cause of six cancers. Despite effective vaccines, HPV vaccination rates remain suboptimal, standing at 26% of females and 9% of males, nationally in 2018. This study assessed factors associated with HPV vaccination uptake among patients at Chicago Department of Public Health (CDPH) STI Specialty Clinics.
View Article and Find Full Text PDFInt J Cancer
September 2025
Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Quebec, Canada.
In Canada, the incidence of human papillomavirus (HPV)-related head and neck cancer (HNC) is increasing. The role of multiple oral HPV infections in HNC etiology remains unclear, and evidence of HPV vaccination's effectiveness in reducing HNC incidence is limited. We investigated oral HPV co-infection patterns, estimated the association between multiple oral HPV infections and HNC risk, and the effect of eliminating vaccine-targeted HPV genotypes on HNC incidence.
View Article and Find Full Text PDFPersistent high-risk human papillomavirus (hHPV) infection, especially HPV-16, plays a central role in the development of high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate the performance of co-testing (cytology and hHPV detection) in a real-world cohort of men who have sex with men (MSM) and transgender women (TW) living with HIV. We conducted a prospective study (2017-2023) at a tertiary care center in Spain.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Department of Epidemiology, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai, China.
Human papillomavirus (HPV) causes multiple diseases in both sexes. This study evaluates the cost-effectiveness and epidemiological impact - defined as reductions in HPV-related disease cases - of a gender-neutral vaccination (GNV) strategy in China's economically developed metropolises: Beijing, Shanghai, and Guangzhou. A discrete-time Markov model simulated no vaccination, female-only vaccination (FOV), and GNV strategies among 12-year-olds.
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