98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996935 | PMC |
http://dx.doi.org/10.1007/s11356-024-32957-z | DOI Listing |
Mol Psychiatry
September 2025
Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, Milan, Italy.
Early-life experiences shape neural networks, with heightened plasticity during the so-called "sensitive periods" (SP). SP are regulated by the maturation of GABAergic parvalbumin-positive (PV+) interneurons, which become enwrapped by perineuronal nets (PNNs) over time, modulating SP closure. Additionally, the opening and closing of SP are orchestrated by two distinct gene clusters known as "trigger" and "brake".
View Article and Find Full Text PDFBackground: One of the most persistent questions in autism research is why males are more consistently diagnosed than females. Neuroimaging studies have sought to understand this disparity by examining sex differences, primarily through functional and structural connectivity. However, much less is known about how brain networks are organized in autism from a morphological perspective, and how this organization may help explain its sex-related characteristics.
View Article and Find Full Text PDFbioRxiv
August 2025
Psychological and Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD.
Intelligent behavior necessitates an adaptive integration of feedback. It is well-known that animals asymmetrically learn from positive and negative feedback. While asymmetrical learning is a robust behavioral effect, the latent computations behind how animals represent their environments and use this to differentially weight wins and losses is poorly understood.
View Article and Find Full Text PDFEJNMMI Res
September 2025
Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
Background: C-acetate positron emission tomography (PET) enables simultaneous quantification of myocardial blood flow (MBF) and oxidative metabolism; however, sex-specific normative data under vasodilator stress remain insufficiently defined. We aimed to characterize these parameters in healthy individuals.
Results: Eighteen healthy individuals (9 males and 9 females, age/sex-matched; median age 43 years [range 34-65]) with normal echocardiography and no underlying cardiovascular disease underwent one-day rest-stress dynamic C-acetate PET with adenosine.
Neuropsychologia
August 2025
The Mind Research Network, a Division of Lovelace Biomedical Research Institute, Albuquerque, 87106, USA.
It is well recognized that adults with exposure to childhood traumas are at risk of developing psychopathology and executive dysfunction. However, how these executive function deficits emerge following trauma exposure has not been widely examined. We hypothesized that children exposed to a higher number of early childhood traumas would show reduced amplitude and longer latency in cortical response in executive brain regions during tasks requiring sustained attention and inhibition, compared to children with fewer or no such experiences.
View Article and Find Full Text PDF