Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Conventional photodynamic therapy (c-PDT) is an effective treatment for actinic keratoses (AKs) and nonmelanoma skin cancer which exploits the photosensitizing properties of methyl aminolaevulinate (MAL). Daylight photodynamic therapy (DL-PDT) is an alternative to c-PDT which does not require the application of MAL in occlusion and that is better tolerated by patients. The impact of occlusion on the efficacy of DL-PD has not been investigated by previous studies.
Objective: To compare the efficacy and tolerability of occlusive and non-occlusive DL-PDT.
Methods: We conducted a prospective intraindividual left/right comparison study. AKs of the face or scalp were marked in two symmetrical treatment areas. The two target areas were randomly assigned to DL-PDT with occlusive and non-occlusive application of MAL. The efficacy and cosmetic outcome were determined by a "blinded" investigator.
Results: Lesions in occluded areas showed a better response in the clearance rate of the lesions (65.5% vs 35.0 %, p < 0.001 %), and cosmetic outcome (P < 0.001). There was no difference in phototoxicity or pain between occluded and non-occluded areas.
Conclusion: The occlusive application of MAL improves the efficacy of DL-PDT in clearing AKs and does not increase the incidence of side effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pdpdt.2024.104049 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Risk Factors for 30-day Mortality After Emergency Surgery for Non-occlusive Mesenteric Ischemia.
In Vivo
August 2025
Department of Gastroenterological Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
Background/aim: Non-occlusive mesenteric ischemia (NOMI) is a rare and highly fatal disease characterized by intestinal ischemia or necrosis despite the absence of obstruction of the mesenteric vessels. This research aimed to investigate the risk factors for 30-day mortality of NOMI after emergency surgery.
Patients And Methods: We analyzed 42 consecutive patients who underwent emergency surgery for NOMI from April 2015 to August 2022.
Microvascular Insights Into Hyaluronic Acid Filler Dispersal Within an Artificial Model of Arterial Embolism.
Aesthet Surg J
August 2025
Merz Aesthetics, Raleigh, NC, USA.
Background: Hyaluronic acid (HA) filler-induced vascular occlusion is a serious complication in aesthetic medicine, yet the microvascular behavior of HA gels under physiologically relevant flow conditions remains poorly characterized.
Objectives: To evaluate the embolic fragmentation, dispersal, and occlusive behavior of five commercially available HA fillers within a physiologically calibrated microvascular perfusion model.
Methods: Five HA fillers were tested using a modified PULSAR system incorporating a branched microtubular adapter (200-1000 µm channels) with physiologic arterial flow parameters.
Superior sagittal sinus dural arteriovenous fistulas: navigating the complexity of treatment strategies and outcomes.
J Clin Neurosci
August 2025
Division of Neurointerventional Radiology, Lahey Hospital & Medical Center - Beth Israel Lahey Health, UMass Chan Medical School, Boston, MA, United States; Department of Medical Imaging, University of Toronto, Canada; Singleton Department of Medical Imaging, Texas Children's Hospital, Baylor Colleg
Background And Purpose: Superior sagittal sinus (SSS) dural arteriovenous fistulas (DAVFs) are sinus-type fistulas with shunting point(s) centered on the sinus or parallel parasinus wall, while its counterpart parasagittal DAVFs are non-sinus-type fistulas with shunting point(s) centered on the junctional zone of the bridging vein and the SSS. SSS DAVFs can be challenging to treat due to the widespread shunting zone, eloquence of the involved venous structure and their rarity. We explore the clinical data, imaging characteristics, endovascular treatment modalities and treatment outcomes of SSS DAVF, with the aim of identifying the ideal treatment strategies.
View Article and Find Full Text PDFDiabetic Ketoacidosis Associated with Non-occlusive Mesenteric Ischemia in a Subject with Type 2 Diabetes Mellitus: A Case Report.
Intern Med
August 2025
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
An 81-year-old man was brought to our institution because of general fatigue, loss of appetite, and decreased consciousness. Based on the clinical findings, the patient was diagnosed with diabetic ketoacidosis (DKA) and started on insulin therapy. Two days after normalization of the ketone body level, he developed a high fever and abdominal pain.
View Article and Find Full Text PDFNon-Occlusive Separate Freezing for Cryoballoon Pulmonary Vein Isolation to the Large Pulmonary Vein.
Pacing Clin Electrophysiol
August 2025
Department of Cardiology, Japan Red Cross Yokohama City Bay Hospital, Yokohama, Japan.
Background: Cryoballoon pulmonary vein (PV) isolation (PVI) requires PV occlusion, which can be challenging to the large PV. The non-occlusive separate freezing, which involves freezing the superior and inferior portions of the PV ostium without complete occlusion, is often useful in these situations. This study aimed to evaluate the efficacy and long-term results of the non-occlusive separate freezing technique and compare the treatment details of POLARx and Arctic Front Advance Pro (AFA-Pro).
View Article and Find Full Text PDF