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The guaianolide family of sesquiterpene lactones is known for its distinctive structural features and diverse biological activities. 4,9,10-Trihydroxyguaia-11(13)-en-12,6-olide, with an underdetermined absolute stereochemistry ( or -), is a newly identified 6,12-guaianolide isolated from the genus . Motivated by the potential biological activity of the natural product, we pursue its stereoselective synthesis.
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