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http://dx.doi.org/10.1002/ajh.27286 | DOI Listing |
J Mol Biol
September 2025
Department of Biochemistry and Biophysics Oregon State University, Corvallis, Oregon, USA. Electronic address:
Ferlins are vesicle trafficking proteins composed of folded C2 domains conjugated by linkers which are largely disordered. Although a role for the C2 domains as calcium sensors has been established it remains unclear whether the linkers function beyond acting as passive spacers. We examined the C2A-C2B linker sequences of vertebrate ferlins and found both putative short linear motifs (SLiMs) as well as membrane binding sequences for members of the protein family.
View Article and Find Full Text PDFCan J Cardiol
September 2025
Division of Cardiology, Hartford HealthCare Heart and Vascular Institute, Hartford, CT, USA. Electronic address:
Post-transplant rejection surveillance remains a cornerstone of heart transplant care. Although endomyocardial biopsy (EMB) has long been the gold standard for detecting rejection, its invasive nature, interobserver variability in histologic interpretation, and limitations in distinguishing between acute cellular rejection (ACR) and antibody-mediated rejection have prompted interest in noninvasive techniques. Traditional biomarkers- such as troponin, C-reactive protein, brain natriuretic peptide, and donor-specific antibodies- offer supplementary assessments of graft function but lack the specificity and sensitivity required to be standalone markers.
View Article and Find Full Text PDFWater Res
August 2025
Department of Civil and Environmental Engineering, Pusan National University, Busan 46241, Republic of Korea; Institute for Environment and Energy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:
Wastewater-based epidemiology (WBE) is increasingly used as a complementary tool for monitoring drug use at the population level, providing anonymized, real-time estimates of community drug consumption. Site-specific applications of WBE can identify localized patterns that national or municipal surveys may overlook. This study presents the first comprehensive, site-specific assessment of illicit drug use in South Korea using WBE.
View Article and Find Full Text PDFNat Aging
September 2025
IFOM-ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.
Aging is the main risk factor for Parkinson's disease (PD), yet our understanding of how age-related mechanisms contribute to PD pathophysiology remains limited. We conducted a longitudinal analysis of blood samples from the Parkinson's Progression Markers Initiative cohort to investigate DNA damage in PD. Patients with PD exhibited disrupted DNA repair pathways and biased suppression of longer transcripts, indicating age-related, transcription-stalling DNA damage.
View Article and Find Full Text PDFSci Rep
September 2025
Fukushima Renewable Energy Institute, Koriyama, 963-0298, Japan.
This study proposes a novel and computationally efficient method for real-time identification and localization of power quality (PQ) disturbances in microgrids using dynamic Lissajous patterns formed by voltage and current waveforms. Each power disturbance-such as sag, swell, harmonic distortion, and transients-induces a unique geometric deformation in the Lissajous figure, which serves as a visual signature of the event. Key geometric and statistical features, including area, skewness, kurtosis, and centroid deviation, are extracted from these dynamic patterns to construct robust indices for classification.
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