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http://dx.doi.org/10.1212/WNL.0000000000209229 | DOI Listing |
Ann Med Surg (Lond)
July 2025
Huntsville Hospital, Huntsville, AL, USA.
Introduction And Importance: Vitamin B6 (pyridoxine) deficiency is a rare but reversible cause of seizures in adults, which is often overlooked in post gastrectomy patients. This case highlights the critical role of nutritional supplementation in preventing severe complications such as neuropsychiatric manifestations and seizures, emphasizing the importance of vigilance in postoperative care and patient follow-up.
Case Presentation: A 46-year-old woman with a history of partial gastrectomy presented with intermittent confusion and somnolence for a duration of 6 months.
Pediatr Neurol
July 2025
Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Background: The use of few-electrode electroencephalography (EEG) for seizure detection in pediatric emergency departments is developing rapidly and is emerging to an important point-of-care bedside test. The aim of this study was to investigate if frontotemporal (FT) electrode placement (F7-T5 and F8-T6) is superior to the usual centroparietal (CP) electrode placement (C3-P3 and C4-P4) in seizure detection, when point-of-care two-channel EEG (tcEEG) is applied.
Method: We reviewed a sample of 38 prerecorded long-term EEGs (gold standard, international 10-20 EEG system) with prior detected electrographic epileptic seizures in children (38 participants, median age, 10.
J Neurol Sci
September 2025
Columbia Center for Translational Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States of America; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States of America.
Background & Objectives: Seizures are a recognized complication of immune effector cell-associated neurotoxicity syndrome (ICANS) from chimeric antigen receptor T cell therapy (CAR-T). Our objective was to characterize continuous (electroencephalogram) EEG data during ICANS to understand EEG patterns in the broader clinical context.
Methods: Clinical and EEG data was collected retrospectively from 2018 to 2023 in patients who underwent CAR-T for cancer and subsequently developed ICANS.
Transl Pediatr
June 2025
Department of Neurology, Children's Hospital of Soochow University, Suzhou, China.
Background: Pathogenic variants in , encoding the GluN2A subunit of the N-methyl-D-aspartate receptor (NMDAR), are increasingly recognized as causes of neurodevelopmental disorders, particularly within the epilepsy-aphasia spectrum. However, presentations without clinical seizures-especially those initially manifesting as isolated ataxia-are rarely reported. We describe a previously unreported frameshift variant associated with early-onset ataxia, delayed-onset electrographic abnormalities, and favorable response to immunotherapy.
View Article and Find Full Text PDFSeizure
August 2025
Program in Neuroinfectious Diseases, Department of Neurology, Columbia University Irving Medical Center, New York Presbyterian Hospital, New York, NY, USA. Electronic address:
Background: There is a paucity of information on factors that could identify patients hospitalized with autoimmune encephalitis at risk of developing acute symptomatic seizures.
Methods: In this retrospective cohort study, patients hospitalized with probable or definite AE who underwent an electroencephalogram (EEG) were identified from two tertiary care centers located in New York (NY, USA) between 2010 and 2021. Electrographic, immunologic, and clinical features associated with the development of seizures were incorporated into a logistic regression model using a stepwise forward model.