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Article Abstract
Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 and D-ring modifications of isosteviol. These compounds were screened for their cytotoxic activities against Hela and A549 cells . Among them, the inhibitory effect of compounds and on Hela cells was comparable to that of the positive control gefitinib, and the compounds (IC=7.84 ± 0.84 μM) and (IC=6.89 ± 0.33 μM) exhibited significant cytotoxicity superior to gefitinib (IC=11.02 ± 3.27 μM) against A549 cells.
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| http://dx.doi.org/10.1080/10286020.2024.2324082 | DOI Listing |
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