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http://dx.doi.org/10.1038/s41380-024-02494-9 | DOI Listing |
Psychiatry Res Neuroimaging
August 2025
Faculty of Social Science, University of Ottawa, Canada.
Background: Childhood sexual abuse (CSA) can cause lasting neurodevelopmental changes, posing significant challenges for survivors. Its specific impact on men remains heavily stigmatized and under-researched. This study examined neurophysiological correlates of CSA in men using diffusion tensor imaging (DTI).
View Article and Find Full Text PDFClin Nutr
August 2025
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Background & Aims: Circulating proteins are integral to many biological processes and could be influenced by diet. We aimed to assess differences in the plasma proteome between people of different dietary groups, defined by degree of animal food consumption.
Methods: The UK Biobank recruited middle-aged adults (mostly 40-69 years) throughout the UK between 2006 and 2010.
Neurology
September 2025
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, MA.
Background And Objectives: Moderate-to-severe traumatic brain injury (TBI) can result in disability across physical, social, and cognitive domains. The Glasgow Outcome Scale-Extended (GOSE), which evaluates global function, is the most frequently used TBI outcome measure. However, the GOSE may not capture all domains of recovery.
View Article and Find Full Text PDFOphthalmol Sci
July 2025
Japan Community Healthcare Organization, Tokyo, Japan.
Purpose: We report the efficacy and safety of voretigene neparvovec (VN) as an adeno-associated viral vector-based gene therapy for Japanese patients with inherited retinal dystrophy caused by biallelic pathogenic variants (-retinopathy).
Design: Open-label, single arm, phase III clinical trial.
Participants: Four subjects were recruited based on the following criteria: (1) a clinical and molecular genetic diagnosis of -retinopathy; (2) age ≥4 years; (3) a best-corrected VA (BCVA) worse than 20/60 or a visual field (VF) <20° by a III4e isopter or equivalent; and (4) sufficient viable retinal cells by OCT or ophthalmoscopy.
Background: Peak oxygen uptake (VO peak), standardized to total body mass (ml/kg/min) is a predictor of morbidity and mortality in cardiovascular disease patients. However, subsets of individuals undergoing exercise based cardiac rehabilitation (CR) show no improvement or reduction in VO peak despite improvement in other functional measures. Our aim is to assess the influence of CR on lean mass, and the effect of body composition compared to total body mass changes on peak VO following CR.
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