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http://dx.doi.org/10.3389/fnut.2024.1375449 | DOI Listing |
Int J Radiat Oncol Biol Phys
October 2025
Department of Radiation Oncology, Stanford University, Stanford, California.
Cancer Lett
September 2025
Department of Cell, Development and Cancer Biology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR, USA; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, OR, USA.
Gemcitabine, a ribonucleotide reductase (RNR) inhibitor, is active in pancreatic ductal carcinoma (PDAC) patients, but unfortunately has a limited impact on long term outcomes. Gemcitabine induces nucleotide deficiency, DNA damage including single stranded DNA (ssDNA) and replication stress (RS). DNA damage can activate cyclic GMP-AMP synthase (cGAS), leading to genome instability, micronucleus generation, and immune activation.
View Article and Find Full Text PDFArthroscopy
September 2025
University of Pittsburgh Medical Center, Department of Orthopaedic Surgery. Electronic address:
Recurrent anterior instability with glenoid bone loss is a difficult problem with several surgical options. The Latarjet technique remains the gold standard for glenoid bone reconstruction in the setting of critical glenoid bone loss with excellent long-term outcomes. However, this technique has well known downsides including high rates of complications.
View Article and Find Full Text PDFNeuromodulation
September 2025
Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA. Electronic address:
Objective: This systematic review and meta-analysis evaluates the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in improving gastric motility in patients with Parkinson's disease (PD).
Materials And Methods: A systematic search was conducted in Scopus, Web of Science, PubMed, and Cochrane CENTRAL until December 15, 2024. Observational studies and clinical trials evaluating DBS effects on gastric motility and gastric emptying in patients with PD were included.