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Article Abstract
The synthesis of tetra-substituted pyrazoles holds significant synthetic value and has been accomplished through an organo-photocatalyzed decarboxylative intramolecular cyclization using readily available 1,2-diaza-1,3-dienes and α-ketoacids. This method allows for the systematic synthesis of substituted pyrazole derivatives. Notably, this approach is characterized by its metal-free and oxidant-free nature, offering distinct advantages such as short reaction times and exceptionally mild reaction conditions. The developed methodology enables the efficient construction of tetra-substituted pyrazoles, expanding the available chemical space for exploration and opening up potential applications in various scientific fields.
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Article Synopsis
- The synthesis of tetra-substituted pyrazoles is achieved through a new method involving organo-photocatalyzed decarboxylative intramolecular cyclization using 1,2-diaza-1,3-dienes and α-ketoacids.
- This method is notable for being metal-free and oxidant-free, which results in shorter reaction times and milder conditions.
- The technique enhances the ability to create different pyrazole derivatives, broadening possibilities for future research and applications in various scientific areas.