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Introduction: Older adults experiencing subjective cognitive decline (SCD) have a higher risk of dementia. Reducing this risk through behavioral interventions, which can increase emotional well-being (mindfulness and compassion) and physical activity, is crucial in SCD.
Methods: SCD-Well is a multicenter, observer-blind, randomized, controlled, superiority trial. Three hundred forty-seven participants (mean [standard deviation] age: 72.7 [6.9] years; 64.6% women) were recruited from memory clinics in four European sites to assess the impact of an 8-week caring mindfulness-based approach for seniors (CMBAS) and a health self-management program (HSMP) on mindfulness, self-compassion, and physical activity.
Results: CMBAS showed a significant within-group increase in self-compassion from baseline to post-intervention and both a within- and between-group increase to follow-up visit (24 weeks). HSMP showed a significant within- and between-group increase in physical activity from baseline to post-intervention and to follow-up visit.
Discussion: Non-pharmacological interventions can differentially promote modifiable factors linked to healthy aging in older adults with SCD.
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http://dx.doi.org/10.1002/dad2.12558 | DOI Listing |
ESC Heart Fail
September 2025
Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Heart failure (HF) is a multifactorial and pathophysiological complex syndrome, involving not only neurohormonal activation but also oxidative stress, chronic low-grade inflammation, and metabolic derangements. Central to the cellular defence against oxidative damage is nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that orchestrates antioxidant and cytoprotective responses. Preclinical in vitro and in vivo studies reveal that Nrf2 signalling is consistently impaired in HF, contributing to the progression of myocardial dysfunction.
View Article and Find Full Text PDFAnn Geriatr Med Res
September 2025
Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Background: Poor hand dexterity may increase the risk of functional disability; however, few studies have examined the relationship between hand dexterity and incident functional disability. The aim of this study was to prospectively investigate the dose-response association of hand dexterity with incident functional disability in community-dwelling older adults.
Methods: This study included 1,069 older adults aged ≥65 years in Kasama City, Japan.
Mater Horiz
September 2025
New Cornerstone Science Laboratory, State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
Dispersing iridium onto high-specific-surface-area supports is a widely adopted strategy to maximize iridium utilization in anode catalysts of proton exchange membrane water electrolysis (PEMWE). However, here we demonstrate that the overall cell performance, including initial efficiency and long-term stability, does not benefit from the typical high specific surface area of catalyst supports. The conventional understanding that high iridium utilization on high-specific-surface-area supports increases activity holds only in aqueous electrolytes, while under the typical working conditions of PEMWE, the mass transport within the anode catalyst layers plays a more significant role in the overall performance.
View Article and Find Full Text PDFMov Disord Clin Pract
September 2025
Department of Physical Medicine and Rehabilitation, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.
Background: The Scale for the Assessment and Rating of Ataxia (SARA) is the most used outcome measure in clinical trials for cerebellar ataxias. The minimal clinically important difference (MCID), a parameter used to assess meaningful change, is not clearly defined.
Objective: To help define MCID for SARA.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China.
Multimorbidity of chronic diseases is one of the most common health issues among older adults, and the resulting demand for long-term medical care and management imposes a considerable burden on healthcare systems. Muscle strength, a core indicator of overall health status, is closely associated with the risk of developing multimorbidity of chronic diseases in older adults. Decline in muscle strength not only increases the risk of multimorbidity of chronic diseases but also interacts with it to exacerbate disease burden.
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