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Introduction: Computer navigation results in better radiological alignment in total knee replacement (TKR). However, functional and clinical outcomes are equally good in conventional TKR. This study aims to compare the functional and clinical outcomes in patients undergoing navigated and conventional TKR.
Methods: A prospective randomized study between navigated TKR (NKR/Group I) and conventional TKR (CKR/Group II) was carried out. Functional outcome was analyzed using the Oxford Knee Score (OKS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) score. Clinical outcome was evaluated as knee range of motion.
Results: Thirty-nine patients (68 knees) were randomized into two groups: I and II. The mean follow-up was 26 months. There was no statistically significant difference between the two groups with respect to knee range of motion, OKS, and WOMAC score at the final follow-up.
Conclusion: We concluded that there is no difference in clinical and functional outcomes between navigated and conventional TKR.
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http://dx.doi.org/10.7759/cureus.53226 | DOI Listing |
JMIR Hum Factors
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KK Women's and Children's Hospital, Singapore, Singapore.
Background: Breast cancer treatment, particularly during the perioperative period, is often accompanied by significant psychological distress, including anxiety and uncertainty. Mobile health (mHealth) interventions have emerged as promising tools to provide timely psychosocial support through convenient, flexible, and personalized platforms. While research has explored the use of mHealth in breast cancer prevention, care management, and survivorship, few studies have examined patients' experiences with mobile interventions during the perioperative phase of breast cancer treatment.
View Article and Find Full Text PDFJ Alzheimers Dis
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Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Università Campus Bio-Medico di Roma, Roma, Italy.
BackgroundAlzheimer's disease (AD) is the most common neurodegenerative disorder. While AD diagnosis traditionally relies on clinical criteria, recent trends favor a precise biological definition. Existing biomarkers efficiently detect AD pathology but inadequately reflect the extent of cognitive impairment or disease heterogeneity.
View Article and Find Full Text PDFSci Prog
September 2025
Shenzhen University Sixth Affiliated Hospital, Shenzhen Nanshan People's Hospital, Shenzhen, China.
Colorectal cancer ranks among the most prevalent and lethal malignant tumors globally. Historically, the incidence of colorectal cancer in China has been lower than that in developed European and American countries; however, recent trends indicate a rising incidence due to changes in dietary patterns and lifestyle. Lipids serve critical roles in human physiology, such as energy provision, cell membrane formation, signaling molecule function, and hormone synthesis.
View Article and Find Full Text PDFClin Orthop Relat Res
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Leni & Peter W. May Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Peripheral nerve injury commonly results in pain and long-term disability for patients. Recovery after in-continuity stretch or crush injury remains inherently unpredictable. However, surgical intervention yields the most favorable outcomes when performed shortly after injury.
View Article and Find Full Text PDFClin Appl Thromb Hemost
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Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Hemophilia, an X-linked monogenic disorder, arises from mutations in the or genes, which encode clotting factor VIII (FVIII) or clotting factor IX (FIX), respectively. As a prominent hereditary coagulation disorder, hemophilia is clinically manifested by spontaneous hemorrhagic episodes. Severe cases may progress to complications such as stroke and arthropathy, significantly compromising patients' quality of life.
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