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Predicting the evolution of systems with spatio-temporal dynamics in response to external stimuli is essential for scientific progress. Traditional equations-based approaches leverage first principles through the numerical approximation of differential equations, thus demanding extensive computational resources. In contrast, data-driven approaches leverage deep learning algorithms to describe system evolution in low-dimensional spaces. We introduce an architecture, termed Latent Dynamics Network, capable of uncovering low-dimensional intrinsic dynamics in potentially non-Markovian systems. Latent Dynamics Networks automatically discover a low-dimensional manifold while learning the system dynamics, eliminating the need for training an auto-encoder and avoiding operations in the high-dimensional space. They predict the evolution, even in time-extrapolation scenarios, of space-dependent fields without relying on predetermined grids, thus enabling weight-sharing across query-points. Lightweight and easy-to-train, Latent Dynamics Networks demonstrate superior accuracy (normalized error 5 times smaller) in highly-nonlinear problems with significantly fewer trainable parameters (more than 10 times fewer) compared to state-of-the-art methods.
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http://dx.doi.org/10.1038/s41467-024-45323-x | DOI Listing |
J Environ Manage
September 2025
University of Maryland Center for Environmental Science, Annapolis, MD, USA.
River water quality degradation is a prevailing problem in coastal China with intensifying human-nature interaction. However, the spatial and temporal dynamics of water quality and their drivers remain poorly understood. In this study, we developed an analytical framework integrating self-organizing mapping (SOM) with partial least squares structural equation models (PLS-SEMs) to analyze the patterns and drivers of river water quality at 49 stations from 2021 to 2023 in Fujian Province, a coastal region in southeastern China.
View Article and Find Full Text PDFDevelopment
September 2025
Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720, USA.
Organ initiation is often driven by extracellular signaling molecules that activate precursor cells competent to receive and respond to a given signal, yet little is known about the dynamics of competency in space and time during development. Teeth are excellent organs to study cellular competency because they can be activated with the addition of a single signaling ligand, Ectodysplasin (Eda). To investigate the role of Eda in tooth specification, we generated transgenic sticklebacks and zebrafish with heat shock-inducible Eda overexpression.
View Article and Find Full Text PDFBr J Sociol
September 2025
Department of Sociology, National University of Singapore, Singapore.
While there is a growing body of literature examining platform dependence and its implications for mental health, much of the research has focused on gig workers with small sample sizes. The lack of large-scale quantitative research, particularly using longitudinal representative data, limits a comprehensive understanding of the dynamic relationship between platform dependence and mental distress. This study uses nationally representative data from the UK and fixed effects models to explore the heterogeneity of gig work, specifically examining differences in mental distress between high-dependence workers (those solely engaged in gig work) and low-dependence workers (those also employed in other jobs).
View Article and Find Full Text PDFBMJ Glob Health
September 2025
Aix-Marseille Univ, IRD, SSA, MINES, Marseille, France.
Introduction: Several sub-Saharan African countries are launching malaria vaccination programmes for children. We assessed how attitudes to malaria vaccination for children could be better understood by considering the individual dynamics of COVID-19 vaccine intention/uptake over the 2021-2023 campaigns, with a view to highlighting barriers likely to affect malaria vaccine uptake.
Methods: We conducted a six-wave telephone-based survey of 600 randomly selected Senegalese households.
Blood
September 2025
The University of Chicago, Chicago, Illinois, United States.
Long-term maintenance of somatic stem cells relies on precise regulation of self-renewal and differentiation. Understanding the molecular framework for these homeostatic processes is essential for improved cellular therapies and treatment of myeloid neoplasms. CUX1 is a widely expressed, dosage-sensitive transcription factor crucial in development and frequently deleted in myeloid neoplasia in the context of -7/(del7q).
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