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Attitudes to malaria vaccination in children: what can be learned from their consistency with the temporal dynamics of COVID-19 vaccination intention? A prospective cohort study in rural Senegal (July 2020-November 2023).
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Introduction: Several sub-Saharan African countries are launching malaria vaccination programmes for children. We assessed how attitudes to malaria vaccination for children could be better understood by considering the individual dynamics of COVID-19 vaccine intention/uptake over the 2021-2023 campaigns, with a view to highlighting barriers likely to affect malaria vaccine uptake.
Methods: We conducted a six-wave telephone-based survey of 600 randomly selected Senegalese households.
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The Cox model and its extensions assuming proportional hazards is widely used to estimate vaccine efficacy (VE). However, when VE wanes over time, estimates can become sensitive to study duration and timing of vaccine delivery relative to disease seasonality, and may be biased due to sample attrition. Additionally, estimates of vaccine impact such as number of cases averted (NCA) are sensitive to background disease incidence and timing of vaccine delivery.
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