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Background: Considering the different calibration and masking of the noise, the adaptive Freiburg monosyllabic speech test in noise (aFBE-S) and the Oldenburg sentence test in noise (OLSA-S) were shown to be comparable with respect to the accuracy of both tests in a previous study. However, the time requirement of the aFBE-S was significantly greater than that of the OLSA-S due to the adaptive measurement method. The purpose of this study is to theoretically determine whether the aFBE-S can be used with fewer test lists, given the low scatter of results, and to compare the results with those of the OLSA-S.
Methods: Using the results of 40 otologically healthy subjects who had already been tested in randomized order with the OLSA-S and aFBE-S, the mean difference of the 95 % confidence interval (95 % CI) of the signal-to-noise ratio for 50% speech understanding (S/N50) of the aFBE-S was calculated for three, four, and five test lists instead of 7.5. In addition, the time required for the reduced number of test lists was determined and the results were examined in comparison with those of the OLSA-S.
Results: In each case, no significant difference between the difference mean of the 95 %-CI of the S/N50 of the original aFBE-S, the aFBE-S shortened to 3, 4, or 5 test lists and the OLSA-S could be found. The time required for the aFBE-S with a reduced number of test lists was significantly less than for the OLSA-S in each case.
Conclusion: The aFBE-S is not inferior with a reduced number of test lists in comparison to the OLSA-S. This would allow to use the shortened aFBE-S theoretically.
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http://dx.doi.org/10.1055/a-2235-0873 | DOI Listing |
Drugs Aging
September 2025
Dalla Lana School of Public Health, University of Toronto, V1 06, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Background And Objectives: Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challenging. Unsupervised machine learning is a group of computing methods that rely on unlabeled data-that is, where the algorithm itself is discovering patterns without the need for researchers to label the data with a known outcome. These methods may help us to better understand complex prescribing patterns in this population.
View Article and Find Full Text PDFExp Clin Transplant
August 2025
>From King Abdullah Medical City, Makkah, Kingdom of Saudi Arabia.
Objectives: Patients who reach the terminal phase of renal disease are candidates for kidney transplant. However, the pretransplant process is substantial and requires time-intensive evaluations. We aimed to investigate the factors that affect the timeline for evaluation of kidney transplants and to identify the challenges and recommendations for improvement of the evaluation process in Saudi Arabia.
View Article and Find Full Text PDFJ Colloid Interface Sci
September 2025
Department of Thermal Science and Energy Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, PR China. Electronic address:
Heterojunctions have garnered significant attention in the field of photocatalysis due to their exceptional ability to facilitate the separation of photogenerated charge carriers and their high efficiency in hydrogen reaction. However, their overall photocatalytic performance is often constrained by electron transport rates and suboptimal hydrogen adsorption/desorption kinetics. To address these challenges, this study develops a g-CN/MoS@MoC dual-effect synergistic solid-state Z-type heterojunction, synthesized through the in-situ sulfurization of MoC combined with ultrasonic self-assembly technique.
View Article and Find Full Text PDFInt J Clin Pharm
September 2025
Heidelberg University, Medical Faculty Heidelberg / Heidelberg University Hospital, Internal Medicine IX - Department of Clinical Pharmacology and Pharmacoepidemiology, Cooperation Unit Clinical Pharmacy, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Introduction: Medication history taking at hospital admission is still prone to errors. Despite numerous quality improvement initiatives, new strategies to improve medication history taking are still sought and evaluated. Unfortunately, the gold standard research methodology for evaluation is resource-intensive, as it requires each patient to complete two medication history interviews.
View Article and Find Full Text PDFJ Hum Genet
September 2025
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.
In standard short-read whole-exome sequencing (WES), capture probes are typically designed to target the protein-coding regions (CDS), and regions outside the exons-except for adjacent intronic sequences-are rarely sequenced. Although the majority of known pathogenic variants reside within the CDS as nonsynonymous variants, some disease-causing variants are located in regions that are difficult to detect by WES alone, such as deep intronic variants and structural variants, often requiring whole-genome sequencing (WGS) for detection. Moreover, WES has limitations in reliably identifying pathogenic variants within mitochondrial DNA or repetitive regions.
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