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Human milk oligosaccharide (HMO) consumption by the infant microbiota is positively associated with immune health. In this issue of Cell Host & Microbe, Buzun et al. report a mechanism for HMO digestion by Bacteroides fragilis and demonstrate how the same pathway works on intestinal mucus to establish long-term gut residency.
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http://dx.doi.org/10.1016/j.chom.2024.01.007 | DOI Listing |
Food Funct
July 2025
HiPP GmbH & Co. Vertrieb KG, 85276 Pfaffenhofen/Ilm, Germany.
Early gut homeostasis is a balance between dietary antigen exposure, gut barrier function, microbiome establishment and orchestration of innate and adaptive immune responses. Imbalances during this early time of development can lead to increased susceptibility to immune reactions like allergy. Especially for infants with a predisposition to allergies and who cannot be exclusively breastfed, there are different human milk substitutes, including hydrolyzed infant formula, which are supposed to prevent allergy-associated mechanisms.
View Article and Find Full Text PDFRespir Res
July 2025
Department of Respiratory and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. xiejjgg@hotmai
Background: Neutrophilic asthma, characterized by the relative accumulation of neutrophils in the airways, constitutes a distinct endotype of asthma resistant to corticosteroid and associated with severe and uncontrolled cases. Milk fat globule-EGF factor 8 (MFGE8) is a soluble glycoprotein functioning in phagocytosis, tissue repair, angiogenesis, and the regulation of neutrophil activity. However, the role of this glycoprotein in neutrophilic asthma has not been thoroughly investigated.
View Article and Find Full Text PDFFEMS Microbiol Ecol
July 2025
Laboratory of Microbiology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Glycans are crucial for infant gut microbiota development. Human milk contains prebiotic human milk oligosaccharides (HMOs) that stimulate gut microbes. Simultaneously, the glycan-rich mucus layer develops and attracts mucin glycan-degrading bacteria.
View Article and Find Full Text PDFFood Funct
July 2025
Institut NuMeCan, INRAE, INSERM, Univ Rennes, F-35000 Rennes, France.
Human milk (HM) is a complex food that meets nutritional newborn needs. The role of its bioactive components, particularly metabolites, in neonatal development remains poorly understood. This study focused on evaluating the effects of HM short chain fatty acids (SCFA), polyamines, tryptophan derivatives, gamma-aminobutyric acid (GABA), serotonin and lactate on several neonatal gut functions.
View Article and Find Full Text PDFJ Dairy Sci
August 2025
Department of Theriogenology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
We hypothesized that prepartum supplementation of fat in a short dry period would improve postpartum energy balance (EB) and produce milk comparable to the traditional dry period. The objective was to investigate the effect of dry period length and prepartum fat supplementation on DMI, EB, BCS, milk yield, and uterine health. The experiment was a randomized complete block design.
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