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Purpose: Determine the pediatric prevalence of keratoconus (KC) using Scheimpflug corneal tomography.
Methods: A prospective observational study was done on subjects aged 3 to 18 years at the Princeton Vision Clinic, Chicago, IL. Scheimpflug tomography (Pentacam HR, OCULUS Optikgerate GmbH) scans (Belin/Ambrósio Enhanced Ectasia BAD3) yielded BAD Final D (Final D) and Back Elevation at the Thinnest Point (BETP) measurements. Criteria differentiating non-KC from KC suspects & KC were, Non-KC -Final D <2.00 in both eyes; KC suspect -Final D ≥2.00 and <3.00 in combination with BETP ≥18 μm for myopia and ≥28 μm for hyperopia/mixed astigmatism in at least one eye; and KC -Final D of ≥3.00 with BETP ≥18 μm for myopia or ≥28 μm for hyperopia/mixed astigmatism in at least one eye. Two thousand two hundred and six subjects were recorded, removing duplicate and poor-quality scans leaving 2007 subjects.
Results: Of 2007 subjects, six were classified as KC -prevalence of 1:334, three subjects were KC suspects -prevalence of 1:669, and total prevalence of KC suspects and KC was 1:223.
Conclusion: The prevalence of KC in children is higher than previously reported, emphasizing the importance of sensitive screening for KC at its earliest manifestation as standard in pediatric comprehensive eye examinations.
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http://dx.doi.org/10.1097/ICL.0000000000001072 | DOI Listing |
Clin Exp Ophthalmol
September 2025
Health New Zealand Tairawhiti, Gisborne, New Zealand.
Background: The prevalence of keratoconus in New Zealand is higher compared to the global prevalence of 1.38 per 1000, with Māori and Pacific Islander being over-represented. The form of keratoconus in New Zealand has been shown to have a more rapid progression of disease.
View Article and Find Full Text PDFInt Ophthalmol
September 2025
People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical College of Ningxia Medical University, Yinchuan, China.
Purpose: Keratoconus (KC) is a bilateral, asymmetric disease causing corneal thinning, irregular astigmatism, and vision decline, with unclear etiology. This study aims to investigate pathogenic variants of candidate genes in Chinese KC families via whole exome sequencing (WES).
Methods: The Pentacam 3D anterior segment analysis system was applied for keratectasia detection, and the Corvis ST was used for corneal biomechanics measurement.
Biomedicines
August 2025
Department of Optometry and Vision Science, Jerusalem Multidisciplinary College, Jerusalem 91010, Israel.
: Dry eye (DE) can cause persistent eye rubbing, contributing to keratoconus (KC) development and progression. Both keratoconus (KC) and dry eye (DE) significantly impact patients' functional and emotional well-being, with KC patients exhibiting a higher prevalence of DE symptoms and signs. This study examined whether functional (KEPAQ-F) and emotional (KEPAQ-E) quality of life, assessed by the Keratoconus End-Points Assessment Questionnaire, differ when influenced by symptoms and clinical signs of general DE versus meibomian gland dysfunction (MGD) in KC patients.
View Article and Find Full Text PDFInt Ophthalmol
August 2025
Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: To assess the incidence rate of corneal haze after combined simultaneous photorefractive keratectomy (PRK) and accelerated (10-min, 9 mW/cm) corneal cross-linking (CXL) for non-keratoconus.
Methods: This is a retrospective cohort study on patients without keratoconus underwent simultaneous CXL-PRK. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), manifest refraction, corneal keratometry, and corneal haze were evaluated.
Cornea
August 2025
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada; and.
Purpose: To estimate global incidence and prevalence trends of keratoconus (KC).
Methods: A systematic review and meta-analysis was conducted using MedLine, Embase, and Scopus databases up to January 2024, including all age groups, sexes, and geographic regions. Pooled incidence and prevalence were estimated using random-effects models, with heterogeneity assessed by χ2 and I2 statistics.