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http://dx.doi.org/10.1016/j.pathol.2023.10.024 | DOI Listing |
Curr Oncol
July 2025
Department of Orthopedics Surgery, King Saud Medical City, Riyadh 1211, Saudi Arabia.
Osteosarcoma is one of the most common primary bone malignancies, typically occurring around the knee. However, the forearm is a rare site, with tumors in the proximal ulna being extremely uncommon. Primary sarcoma in this location presents a surgical challenge due to the complex anatomy and limited reconstructive options.
View Article and Find Full Text PDFSemin Diagn Pathol
September 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Xanthogranulomatous epithelial tumor (XGET) and keratin-positive giant cell-rich tumor (KPGCT) represent ends along the spectrum of a single neoplastic entity, with overlapping clinical, morphologic, immunohistochemical, and genetic findings (XGET/KPGCT). Morphologically, they are characterized by a highly variable admixture of xanthomatous histiocytes, Touton-like giant cells, osteoclast-like giant cells, and interspersed keratin-positive cells, which may be visible on routinely stained slides as clusters of eosinophilic epithelioid cells or require immunohistochemistry for detection. Both XGET and KPGCT harbor rearrangements of HMGA2, most often with NCOR2, supporting their unitary nature.
View Article and Find Full Text PDFSemin Diagn Pathol
September 2025
Department of Anatomic Pathology and Laboratory Medicine, Indiana University, 635 Barnhill Drive, Indianapolis, IN, 46202, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce St., Philadelphia, PA, 19104, USA.
Keratin-positive giant cell-rich tumor is a recently described mesenchymal neoplasm, which occurs predominantly in young women and often arises in the subcutis or bone. Histologically, tumors vary from giant cell tumor-like to xanthogranulomatous, or a mixture of both patterns. Tumors with predominantly xanthogranulomatous infiltrate and scattered mononuclear cells with bright eosinophilic cytoplasm were originally described as xanthogranulomatous epithelial tumor, a lesion which was subsequently found to be on a morphologic spectrum with keratin-positive giant cell-rich tumor.
View Article and Find Full Text PDFActa Orthop Traumatol Turc
May 2025
Department of Pathology, Professor of Pathology, Trakya University Faculty of Medicine, Edirne, Türkiye.
Giant cell-rich osteosarcoma (GCRO) is a rare variant of osteosarcoma with unusual radiological and histopathological features that make its diagnosis challenging. The most critical and unusual feature of GCRO is that it has a purely osteolytic appearance. Therefore, GCRO cases are frequently subject to delayed diagnosis or incorrect treatment owing to misdiagnosis.
View Article and Find Full Text PDFIntroduction: We report the first case of an asymptomatic woman with osteoclast-like giant cell-rich cervical squamous cell carcinoma (OGC-rich cervical SCC), where the detection of cancer was made possible only by routine cytological screening. The presence of OGCs in cervical SCCs is an extremely rare phenomenon, with only 8 cases reported to date.
Case Description: Two consecutive liquid-based cytology revealed high-grade squamous intraepithelial lesion (HSIL).