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Article Abstract
Several genetic investigations were conducted to identify germline and somatic mutations in somatotropinomas, a subtype of pituitary tumors. To our knowledge, we report the first acromegaly patient carrying a pathogenic variant: c.2410G>A (rs79658334), p.Val804Met. Alongside the fact that the patient's father and daughter carried the same variant, we investigated the clinical significance of this variant in the context of somatotropinomas and other endocrine tumors, reviewing the mutations' oncogenic mechanisms. The aim was to search for new targets to precisely manage and treat acromegaly. Our case describes a new phenotype associated with the pathogenic variant, represented by aggressive acromegaly, and suggests consideration for mutation screening if NGS for well-established PitNET-associated gene mutations renders negative.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10856706 | PMC |
| http://dx.doi.org/10.3390/ijms25031895 | DOI Listing |
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