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Contrast-enhanced mammography (CEM) is a relatively recent diagnostic technique increasingly being utilized in clinical practice. Until recently, there was a lack of standardized reporting for CEM findings. However, this has changed with the publication of a supplement in the Breast Imaging Reporting and Data System (BI-RADS). A comprehensive understanding of CEM is essential for further enhancing its role in both screening and managing patients with breast malignancies. CEM can also be beneficial for problem-solving, improving the management of uncertain breast findings. Practitioners in this field should become more cognizant of how and when to employ this technique and interpret the various CEM findings. This paper aims to outline the key findings in the updated version of the BI-RADS specifically dedicated to CEM. Additionally, it will present some clinical cases commonly encountered in clinical practice.Critical relevance statement Standardized reporting and a thorough understanding of CEM findings are pivotal for advancing the role of CEM in screening and managing breast cancer patients. This standardization contributes significantly to integrating CEM as an essential component of daily clinical practice.Key points • A complete knowledge and understanding of the findings outlined in the new BI-RADS CEM are necessary for accurate reporting.• BI-RADS CEM supplement is intuitive and practical to use.• Standardization of the CEM findings enables more accurate patient management.
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http://dx.doi.org/10.1186/s13244-024-01612-z | DOI Listing |
J Am Chem Soc
September 2025
Kathleen Lonsdale Materials Chemistry, Department of Chemistry, University College London, London WC1H 0AJ, U.K.
The exceptional performance of ceria (CeO) in catalysis and energy conversion is fundamentally governed by its defect chemistry, particularly oxygen vacancies. The formation of each oxygen vacancy (V) is assumed to be compensated by two localized electrons on cations (Ce). Here, we show by combining theory with experiment that while this 1 V: 2Ce ratio accounts for the global charge compensation, it does not apply at the local scale, particularly in nanoparticles.
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September 2025
International Osteoporosis Foundation, Nyon, Switzerland.
Unlabelled: The study explored osteoporosis patients' views on the disease in six LATAM countries. All were diagnosed for over 3 years, 65% avoiding fragility fractures. Sixteen used osteoporosis drugs, trusting physicians most.
View Article and Find Full Text PDFEur J Med Chem
August 2025
Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy. Electronic address:
The transcriptional activity of TEAD4 (transcriptional enhancer associated domain proteins), one of the final effectors of the Hippo pathway, can be dysregulated or mutated in cancer. Consequently, targeting the interaction between TEAD and its co-activator YAP (Yes Associated Protein) to disrupt the YAP:TEAD (Y:T) heterodimer has emerged as a promising anti-cancer strategy. Therefore, in this study, we aimed to identify novel scaffolds targeting the TEAD Interface 3 surface as effective anticancer agents against colorectal and ovarian cancer.
View Article and Find Full Text PDFClin Neurophysiol
August 2025
Department of Clinical Neurophysiology. Vall d'Hebron University Hospital. Passeig de la Vall d'Hebron, 119 Barcelona, Spain. Electronic address:
Introduction: Immune checkpoint inhibitors (ICIs) have become key therapies for various malignancies by restoring antitumor immunity. However, they may trigger immune-related adverse events (irAEs), including neurological irAEs (n-irAEs), which, though rare, can be severe. Among these, neuromuscular disorders affecting peripheral nerves, the neuromuscular junction (NMJ), and muscle are the most frequent and carry the highest mortality risk, warranting prompt recognition.
View Article and Find Full Text PDFCureus
July 2025
Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, Bhubaneswar, IND.
Regenerative endodontics utilizes stem cell biology and bioactive materials to restore pulp vitality. Human dental pulp stem cells (hDPSCs), with their self-renewal and odontogenic differentiation potential, are central to regenerative endodontics. Hydraulic calcium silicate-based cements (HCSCs), such as mineral trioxide aggregate (MTA) and Biodentine (Septodont, Saint-Maur-des-Fossés, France), are widely used in vital pulp therapies to promote pulp vitality recovery.
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