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http://dx.doi.org/10.1016/j.jtha.2023.10.030 | DOI Listing |
Carbohydr Polym
November 2025
Zhejiang Key Laboratory of Bioorganic Synthesis, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; Huadong Indust
Heparin, a clinically essential anticoagulant, has long been derived from animal sources, posing risks of contamination and supply chain instability. Bioengineered heparin, synthesized via microbial fermentation and enzymatic modification, offers a promising alternative with enhanced safety, homogeneity, and scalability. This review highlights recent advances in heparosan biosynthesis, enzymatic sulfation strategies, and analytical characterization for bioengineered heparin.
View Article and Find Full Text PDFClin Chem Lab Med
September 2025
Department of cardiology, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.
Objectives: To assess the imprecision and stability of the point-of-care troponin I assay in the Emergency Department and its correlation and bias to two central laboratory troponin I assays (Siemens Atellica and Abbott Alinity).
Methods: Imprecision and stability testing was performed on opportunistically selected samples using whole blood in the emergency department by non-laboratory trained personnel. Assay comparisons were undertaken on samples taken from participants of the Mersey Acute Coronary syndrome Rule Out Study.
Adv Healthc Mater
August 2025
Key Laboratory of Cluster Science, Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Advanced Research Institute of Multidisciplinary Science, Frontiers Science Center for High Energy Material, Advanced Technology Research Institute (Jinan), Schoo
Preventing coagulation during extracorporeal blood circulation is critical for clinical treatments. Developing anticoagulant materials for key components can reduce reliance on systemic anticoagulants and improve safety. However, such materials often show limited efficacy due to inefficient interactions with pro/anti-coagulation components, resulting from random active site distribution and orientation.
View Article and Find Full Text PDFPharmeur Bio Sci Notes
August 2025
Medicines and Healthcare products Regulatory Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK.
The European Pharmacopoeia (Ph. Eur.) prescribes that low-molecular-mass heparin products be calibrated for their molecular mass distribution using a reference preparation with a defined molecular mass calibration.
View Article and Find Full Text PDFTransplant Cell Ther
August 2025
Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Background: With improved survival after allogeneic hematopoietic stem cell transplantation (allo-HSCT), late complications including venous thromboembolism (VTE) have gained clinical importance. However, the incidence and predictive models for late-onset VTE after allo-HSCT are poorly defined, with limited data on subsequent treatment and outcomes.
Objective: To describe the clinical features and outcomes of late-onset VTE and establish a risk prediction model for Japanese patients.