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Preeclampsia (PE) is a disease in pregnancy that is characterized by new-onset hypertension end-organ dysfunction, often occurring after 20 weeks of gestation. Risk factors include a prior history of PE, diabetes, kidney disease, obesity, and high maternal age at pregnancy. Current treatment and management guidelines focus on the management of high blood pressure and any potential complications. The only known curative treatment is termination of pregnancy (either induction of delivery or cesarean section). However, the current guidelines and recommendations lack adequate prediction markers and are unable to prevent maternal and fetal mortality. There also exists a need for multidisciplinary collaborative action in view of the quality of life and psycho-educational counseling.
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http://dx.doi.org/10.7759/cureus.51512 | DOI Listing |
Arch Gynecol Obstet
September 2025
Department of Obstetrics and Gynaecology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Objectives: Recommendations regarding the use of third-trimester ultrasound lack universal consensus. Yet, there is evidence which supports its value in assessing fetal growth, fetal well-being, and a number of pregnancy-related complications. This literature review evaluates the available scientific evidence regarding its applications, usefulness, and the timing of the third-trimester scan in a low-risk population.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
August 2025
Division of Maternal-Fetal Medicine and Surgery, Department of Obstetrics and Gynecology, Hackensack University Medical Center, Hackensack, NJ, USA; Hackensack Meridian School of Medicine, Nutley, NJ, USA.
Objectives: To examine if the postpartum readmission rate was influenced by the use of nifedipine compared with labetalol at discharge in patients with hypertensive disorders of pregnancy.
Study Design: PubMed, ClinicalTrials.gov, Science Direct and the Cochrane Central Register of Controlled Trials were searched from inception to September 2024.
Cureus
August 2025
Department of Obstetrics and Gynecology, Ministry of National Guard Health Affairs, Riyadh, SAU.
This case report discusses the overall care of a female patient with nephrotic syndrome secondary to non-pre-eclampsia-related hypertension in pregnancy, emphasizing the challenges and multidisciplinary treatment needed for desired results. The case presented here involves a 32-year-old pregnant woman with a history of unexplained primary infertility who conceived through in vitro fertilization (IVF). At 26 weeks and three days of gestation, she presented with symptoms suggestive of nephrotic syndrome, including lower limb swelling, facial puffiness, oliguria, and dark-colored urine.
View Article and Find Full Text PDFJ Obstet Gynaecol Res
September 2025
Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, Niigata, Japan.
Aim: This study aimed to investigate maternal and perinatal outcomes in pregnancies among women aged50-54 and 55-59, to refine risk assessments and inform evidence-based counseling and perinatal management guidelines.
Methods: A nationwide registry maintained by the Japan Society of Obstetrics and Gynecology identified pregnancies between January 2013 and December 2022. Analyses included women aged 45-59 years with assisted reproductive technology pregnancies, excluding triplet or higher-order multiple gestations.
Hypertension
September 2025
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom. (J.K., L. Biasiolli, S.K., H.C., A.F., K.S., Y.K., W.L., P.L.).
Background: Hypertensive pregnancy disorders are associated with long-term adverse cardiac and vascular remodeling postindex pregnancy. The POP-HT trial (Physician Optimised Postpartum Hypertension Treatment) demonstrated that improved puerperal blood pressure control leads to reduced blood pressure and beneficial cardiac remodeling during the first year postpartum. This study describes the impact on postpartum vascular remodeling.
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