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http://dx.doi.org/10.1093/eurheartj/ehae067 | DOI Listing |
Eur Heart J Case Rep
September 2025
Cardiology Department, Arrhythmia Section, Virgen del Rocío University Hospital, Avda Manuel Siurot s/n, Seville 41013, Spain.
Background: Bundle branch re-entrant ventricular tachycardia (BBRVT) typically occurs in patients with structural heart disease and conduction abnormalities. Certain genetic mutations may be responsible for conduction disorders leading to BBRVT, especially in young individuals without apparent structural heart disease.
Case Summary: A 17-year-old male with no pathological history was admitted to our institution due to wide QRS complex tachycardia with right bundle branch block morphology and left superior axis.
Stem Cell Res Ther
September 2025
Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan.
Background: Myocardial infarction (MI) results in loss of cardiomyocytes leading to heart failure. Despite advancements in pharmacotherapy and interventions such as revascularization, ischemic heart failure remains a challenge. Recent advancements in stem cell therapies, genetic engineering and bioengineering have shown to improve cardiac function and quality of life.
View Article and Find Full Text PDFEur Heart J Case Rep
August 2025
Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chao Yang District, Beijing 100020, China.
Background: The management of ventricular arrhythmias (VA) following myocardial infarction presents substantial challenges due to the high morbidity and mortality rates, particularly in cases refractory to medical therapy. In certain cases, the arrhythmogenic anatomical substrate is located in the epicardium. Consequently, achieving a transmural injury by endocardial catheter ablation has always been infeasible.
View Article and Find Full Text PDFMater Today Bio
October 2025
Department of Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang province, China.
Myocardial ischemia-reperfusion (MI/R) injury limits the therapeutic effects of revascularization in acute myocardial infarction. In this study, we investigated whether human SIRT3 (hSIRT3) and TIMP3 (hTIMP3) could achieve targeted delivery with the assist of cationic microbubbles (CMBs) and a synergistic protection effect on porcine MI/R myocardium. Firstly, CMBs carrying the hSIRT3 or hTIMP3 plasmids were used individually or synergistically for cardiac-targeted delivery in MI/R pigs.
View Article and Find Full Text PDFInsights Imaging
August 2025
Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Objectives: This study aimed to assess the feasibility of left ventricular myocardial characterization in patients with ventricular arrhythmias using late enhancement (LE) photon-counting detector computed tomography (PCD-CT) scans, in comparison with invasive endocardial electroanatomical mapping (EAM).
Materials And Methods: This single-center retrospective observational study included 20 patients (mean age 64 ± 8 years, 4 female) who underwent PCD-CT prior to 3D endocardial uni- and bipolar EAM and radiofrequency catheter ablation (RFCA) between May 2022 and February 2024. Sixteen patients (80%) had cardiac implantable electronic devices.