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http://dx.doi.org/10.4187/respcare.11811 | DOI Listing |
Int J Pharm
August 2025
Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska 68178, USA. Electronic address:
Direct delivery of Messenger RNA (mRNA) via inhalation to the lungs could revolutionize the treatment of various pulmonary diseases. By utilizing the target's cellular machinery to produce therapeutic proteins, this approach bypasses the challenges and side effects associated with traditional systemic administration. This non-invasive approach holds the potential to improve the treatment of genetic and infectious pulmonary diseases.
View Article and Find Full Text PDFJ Aerosol Med Pulm Drug Deliv
August 2025
Jolyon Mitchell Inhaler Consulting Services Inc., London, Canada.
The "Miller" design of mixing inlet (MI) enables a cascade impactor to operate at a constant flow rate while the orally inhaled product-on-test is evaluated at varying flow rates by controlling the flow of air via its side-arm. As part of the European Pharmaceutical Aerosol Group (EPAG) Impactor subgroup, we report a cross-industry experimental investigation by five organizations to determine internal losses of different inhaler-generated aerosolized medications within commercially available MIs, focusing on pharmacopeial methods for product testing. Evaluations were undertaken of solution and suspension formulations delivered by pressurized metered dose inhalers (pMDIs), passive dry powder inhalers (DPIs), and compressed air-jet and vibrating mesh nebulizers.
View Article and Find Full Text PDFNat Commun
August 2025
Research Center for Advanced Functional Ceramics, Wuzhen Laboratory, Jiaxing, China.
Present main-stream medical ultrasonic nebulizers contain Pb(Zr,Ti)O-based piezoceramics, which could expose the patients to toxic lead when the acidic liquid medicine, compounded with ultrasonic vibration, corrodes the piezoceramics. Enormous amount of lead ions up to 150 ppm can be extracted when lead-containing piezoceramics were exposed to typical acidic liquid medicines. Thus, a series of nebulization in a course of treatment could easily raise a child's blood lead level well above the blood lead reference value of 0.
View Article and Find Full Text PDFEur Clin Respir J
July 2025
Department of Respiratory Therapy, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Introduction: The volume of colistimethate sodium (CMS) that can be administered in a single application using a vibrating mesh nebulizer (VMN) is related to the capacity of the nebulization chamber. This study designed and tested a nebulization chamber and assessed the effects of the diluent volume on colistin nebulization.
Methods: A bench study was conducted to evaluate the performance of the nebulization chamber.
J Aerosol Med Pulm Drug Deliv
July 2025
Department of Cardiopulmonary Sciences, Division of Respiratory Care, Rush University, Chicago, Illinois, USA.
Aerosol delivery via high-flow nasal cannula (HFNC) with an inspiration-synchronized vibrating mesh nebulizer (VMN) yielded higher inhaled doses than with a continuous VMN. Recently, a prototype VMN generating aerosol particles <3 µm improved aerosol delivery during invasive ventilation in adult and pediatric models, outperforming the conventional VMN. However, the effects of inspiration-synchronized small-particle VMN during HFNC remain unknown.
View Article and Find Full Text PDF