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Background: Paraneural sheath engulfing the sciatic nerve (SN) between the ischial tuberosity and the greater trochanter is well known.
Methods: In order to explore the anatomical planes separating the paraneurium from the epineurium in SN, we conducted a cadaveric study (two patients and four specimens), followed by a clinical study in 10 patients.
Results: We demonstrated an elevation of 5-7 layers of paraneural tissues after an in-plane injection in the longitudinal axis of the proximal SN, which was possibly the last of the paraneural sheath. In the clinical study, the block provided low pain scores with no rescue analgesia postoperatively and no neurological deficit at the time of discharge.
Conclusion: This is probably the first series which has described the elevation of several layers of paraneural tissues after an in-plane injection in the longitudinal axis of the proximal SN.
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http://dx.doi.org/10.4103/jmu.jmu_121_22 | DOI Listing |
PLoS Comput Biol
September 2025
Mathematical and Statistical Methods (Biometris), Wageningen University, Wageningen, The Netherlands.
Many plant cell functions, including cell morphogenesis and anisotropic growth, rely on the self-organisation of cortical microtubules into aligned arrays with the correct orientation. An important ongoing debate is how cell geometry, wall mechanical stresses, and other internal and external cues are integrated to determine the orientation of the cortical array. Here, we demonstrate that microtubule-based nucleation can markedly shift the balance between these often competing directional cues.
View Article and Find Full Text PDFJOR Spine
September 2025
Spine Center, Department of Orthopaedics Changzheng Hospital, Naval Medical University (Second Military Medical University) Shanghai People's Republic of China.
Background: Ossification of the posterior longitudinal ligament (OPLL) is a pathological condition characterized by ectopic ossification of spinal ligaments, primarily driven by abnormal osteogenic differentiation of ligament fibroblasts with stem cell-like properties. The SOX transcription factor family is crucial in regulating cell stemness and differentiation. Among them, SOX8 is known to influence osteoblast differentiation, but its role in OPLL remains unclear.
View Article and Find Full Text PDFBackground And Aims: The role of anti-Müllerian hormone (AMH), a potential marker of the hypothalamic-pituitary-ovarian axis, is not well established in adolescent females. Typical epidemiologic studies use secondary sexual characteristics or chronological age as predictors for AMH. Skeletal maturity, an indicator of bone development, however, has not been examined in association with AMH in adolescent females.
View Article and Find Full Text PDFFront Public Health
September 2025
Neurosciences Axis, Centre de Recherche du Centre Hospitalier Universitaire (CRCHU) de Québec-Université Laval, Québec City, QC, Canada.
Introduction: Preventive measures have been implemented in hospitals during COVID-19, but how these guidelines affected mental health among healthcare workers (HCWs) remains to be determined. On another note, reliable psychological and blood-based markers are needed to promptly identify HCWs at-risk to develop distress. Extracellular vesicles (EVs) originating from brain cross the blood-brain barrier and are detectable in blood, giving them a highly valuable potential for biomarker discovery.
View Article and Find Full Text PDFNutr Metab Cardiovasc Dis
July 2025
Instituto de Investigación e Innovación Biomédica de Cádiz, (INiBICA), Cádiz, Spain; GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Puerto Real, Cadiz, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; UGC
Aims: The prevalence of metabolic syndrome (MetS) is increasing annually across all age groups, raising the risk of morbidity, mortality, diabetes and cardiovascular disease in adults, adolescents, and children. Active commuting (AC) provides an opportunity to increase physical activity and reduce the MetS risk. The purpose of this study was to synthesize the available evidence on the prevalence of MetS and MetS risk factors in relation to AC vs non-active commuting among adults, adolescents, and children.
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