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We consider the problem of population density estimation based on location data crowdsourced from mobile devices, using kernel density estimation (KDE). In a conventional, centralized setting, KDE requires mobile users to upload their location data to a server, thus raising privacy concerns. Here, we propose a Federated KDE framework for estimating the user population density, which not only keeps location data on the devices but also provides probabilistic privacy guarantees against a server that tries to infer users' location. Our approach Federated random Fourier feature (RFF) KDE leverages a random feature representation of the KDE solution, in which each user's information is irreversibly projected onto a small number of spatially delocalized basis functions, making precise localization impossible while still allowing population density estimation. We evaluate our method on both synthetic and real-world datasets, and we show that it achieves a better utility (estimation performance)-vs-privacy (distance between inferred and true locations) tradeoff, compared to state-of-the-art baselines (e.g., GeoInd). We also vary the number of basis functions per user, to further improve the privacy-utility trade-off, and we provide analytical bounds on localization as a function of areal unit size and kernel bandwidth.
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http://dx.doi.org/10.56553/popets-2023-0019 | DOI Listing |
Lipids Health Dis
September 2025
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Background: The CRP-albumin-lymphocyte (CALLY) index has potential clinical value as a novel marker integrating inflammatory, nutritional and immune status in the development of colorectal polyps. This study examined whether gender factors influence the association between CALLY and colorectal polyps; in addition to elucidating whether metabolic pathways mediate this relationship.
Methods: This is a cross-sectional study including 5409 adult health screening participants who completed colonoscopy.
Genome Biol
September 2025
Center for Genomic Medicine, Cardiovascular Research Center, , Massachusetts General Hospital Simches Research Center, 185 Cambridge Street, CPZN 5.238,, Boston, MA, 02114, USA.
Background: Rare genetic variation provided by whole genome sequence datasets has been relatively less explored for its contributions to human traits. Meta-analysis of sequencing data offers advantages by integrating larger sample sizes from diverse cohorts, thereby increasing the likelihood of discovering novel insights into complex traits. Furthermore, emerging methods in genome-wide rare variant association testing further improve power and interpretability.
View Article and Find Full Text PDFProc Biol Sci
September 2025
Department of Biology, Emory University, Atlanta, GA, USA.
Crowding can result in greater disease transmission, yet crowded hosts may also remove infectious propagules from the environment, thereby lowering the encounter rate and infectious dose received by conspecifics. We combined experimental and modelling work to examine the impact of crowding of butterfly larvae on the per-capita risk of infection by a protozoan that is transmitted via the larval food plant, and the resulting infection load in adult butterflies. We reared larvae at different densities and exposed them to low and high doses of parasites.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
There is a lack of longitudinal data on type 2 diabetes (T2D) in low- and middle-income countries. We leveraged the electronic health records (EHR) system of a publicly funded academic institution to establish a retrospective cohort with longitudinal data to facilitate benchmarking, surveillance, and resource planning of a multi-ethnic T2D population in Malaysia. This cohort included 15,702 adults aged ≥ 18 years with T2D who received outpatient care (January 2002-December 2020) from Universiti Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.
View Article and Find Full Text PDFGraefes Arch Clin Exp Ophthalmol
September 2025
Department of Physics of Condensed Matter, Optics Area. Vision Research Group (CIVIUS), University of Seville, Avenida de la Reina Mercedes s/n (41012), Seville, Spain.
Purpose: To analyze the relationship between various visual function parameters (refractive status, visual acuity and contrast sensitivity) and macular pigment optical density (MPOD) values, as well as dietary intake of lutein and zeaxanthin in a pediatric population.
Methods: Thirty-six healthy White pediatric patients participated in this cross-sectional study conducted at the Optometry Clinic (Faculty of Pharmacy, Seville, Spain). MPOD values were measured using the MPSII (Macular Pigment Screener II).