Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic dual stenting.
Aims: To estimate the 1-year cost-effectiveness of stepwise provisional versus systematic dual stenting strategies.
Methods: Costs in France and the UK, and MACE were calculated in both groups to estimate the incremental cost-effectiveness ratio (ICER). Uncertainty was explored by probabilistic bootstrapping. The analysis was conducted from the perspective of the healthcare provider with a time horizon of 1 year.
Results: The cost difference between the two groups was €-755 (€5700 in the stepwise provisional group and €6455 in the systematic dual stenting group, p value<0.01) in France and €-647 (€6728 and €7375, respectively, p value=0.08) in the UK. The point estimates for the ICERs found that stepwise provisional strategy was cost saving and improved outcomes with a probabilistic sensitivity analysis confirming dominance with an 80% probability.
Conclusion: The stepwise provisional strategy at 1 year is dominant compared with the systematic dual stenting strategy on both economic and clinical outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806460 | PMC |
| http://dx.doi.org/10.1136/openhrt-2023-002479 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Human Pluripotent Stem Cell-Derived Skeletal Muscle Organoid Model of Aging-Induced Sarcopenia.
J Cachexia Sarcopenia Muscle
August 2025
Department of Pharmacology, Ajou University School of Medicine, Suwon, Gyeonggi-do, Republic of Korea.
Background: Sarcopenia is defined by the age-related loss of muscle mass and function, with an impaired regenerative capacity of satellite cells (SCs). Despite their recognized importance in muscle regeneration, human model-based studies on SCs in sarcopenia are still lacking, limiting our understanding of their role in age-related muscle loss. Here, we aimed to develop a sarcopenia model using human pluripotent stem cells (hPSCs)-derived skeletal muscle organoids (hSkMOs) and prevent the sarcopenia progression by testosterone treatment.
View Article and Find Full Text PDFCirculating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis.
Sci Rep
July 2025
Bone and Joint Center, Henry Ford Health, 6135 Woodward Avenue, Detroit, MI, 48202, USA.
Osteoarthritis (OA) and rheumatoid arthritis (RA) are prevalent joint diseases, yet early diagnosis remains challenging with existing methods. Circulating microRNAs are promising biomarkers for detection and differentiation of arthritis subtypes. This study aimed to profile plasma microRNAs from early OA (N = 22), early RA (N = 12), and non-OA/RA (N = 50) individuals using microRNA-sequencing.
View Article and Find Full Text PDFImpact of iliac artery calcification burden on mid-term outcomes in femoropopliteal artery disease treated with drug-coated balloon combined with provisional bare metal stenting.
Int J Cardiol
September 2025
Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China; Department of Vascular Surgery, Nanjing Drum Tower Hospital, Nanjing Drum Tower Hospital Clinical College, Nanjing University of Chinese Medicine, Jiangsu Nanjing 2
Objective: Severe arterial calcification is an important factor affecting endovascular therapy in patients with the lower extremity atherosclerotic occlusive disease. The aim of this study was to investigate whether different calcification burden of iliac artery is associated with various clinical outcomes following drug-coated balloon (DCB) combined with provisional bare metal stenting for femoral-popliteal artery disease.
Methods: This was a retrospective cohort study of patients who underwent drug-coated balloon combined with stent placement for femoral-popliteal artery disease from January 2018 to July 2022.
Factors Associated With Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection.
Stroke
June 2025
Department of Neurology, Brown Medical School, Providence, RI (D.M.M., L.S., C.C., N.J., K.P., V.D., K.B., T.B., N.K., F. Khan, C.S., N. Mohammadzadeh, E.G., K.F., S. Yaghi).
Background: Patients presenting with cervical artery dissection (CAD) are at risk for subsequent ischemic events. We aimed to identify characteristics that are associated with increased risk of ischemic stroke after initial presentation of CAD and to evaluate the differential impact of anticoagulant versus antiplatelet therapy in these high-risk individuals.
Methods: This was a preplanned secondary analysis of the STOP-CAD study (Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection), a multicenter international retrospective observational study (63 sites from 16 countries in North America, South America, Europe, Asia, and Africa) that included patients with CAD predominantly between January 2015 and June 2022.
Comparison of Stent Geometry Achieved by Different Side-Branch Ballooning Techniques For Bifurcation Provisional Stenting: The CRABBIS Trial.
JACC Cardiovasc Interv
May 2025
Department of Cardiovascular and Pulmonary Sciences, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Electronic address:
Background: Stepwise provisional stenting is the most adopted approach for percutaneous coronary interventions (PCIs) in bifurcation lesions. During these procedures, the side branch (SB) may deserve treatment, but the best ballooning technique is still undetermined.
Objectives: The study sought to compare the stent configurations obtained by 2 SB ballooning sequences after main vessel (MV) stent implantation: the proximal optimization technique + kissing balloon inflation + final proximal optimization technique (PKP) vs the proximal optimization technique + isolated side branch dilation + final proximal optimization technique (PSP).