Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: To evaluate the clinical outcome of subretinal autologous internal limiting membrane (ILM) transplantation during pars-plana vitrectomy for persistent full-thickness macular hole (FTMH) repair.
Methods: Retrospective, consecutive case series of 13 eyes (13 patients) undergoing small-incision vitrectomy with ILM transplantation and air tamponade for large persistent FTMH after prior unsuccessful vitrectomy with posterior hyaloid detachment and ILM peeling.
Main Outcome Measurements: For all eyes, high-definition spectral domain optical coherence tomography scans (SD-OCT Spectralis, Heidelberg Engineering GmbH, Germany) of the macula were routinely performed before surgery, 1 and 4 weeks after surgery, and at the final follow-up visit. Additionally, age, gender, axial length, macular hole diameter, biomicroscopic fundus evaluation and best-corrected visual acuity (BCVA) at baseline, 1 and 4 weeks after surgery, and at the final follow-up visit were analyzed.
Results: Anatomic closure was achieved in all 13 cases (100% success rate). Closure pattern was classified in accordance with to Rossi et al. (Graefe's Arch Clin Exp Ophthalmol 258(12):2629-2638, 2020). Mean baseline BCVA logMAR was 0.93, mean postoperative BCVA logMAR was 0.66 with a mean postoperative follow-up period of 11.4 months. No re-opening occurred during the observation period.
Conclusions: Placing an autologous ILM-transplant in the subretinal space beneath the margin of the FTMH can support anatomic restauration and functional improvement in large, persistent FTMHs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10797851 | PMC |
| http://dx.doi.org/10.1186/s40942-023-00524-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A clinical practice review: management strategies and emerging approaches for anastomotic leakage following radical surgery for esophageal cancer.
Ann Palliat Med
September 2025
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Radical esophagectomy remains the cornerstone of curative treatment for esophageal cancer, but is frequently complicated by postoperative events, most notably anastomotic leakage. Anastomotic leakage, occurring in up to 30% of cases, is multifactorial in origin and significantly increases morbidity and mortality. This review aims to summarize current management strategies, highlight emerging therapies, and identify persistent clinical challenges related to this complication.
View Article and Find Full Text PDFDecompensation of degenerative lumbar stenosis: do patients need immediate surgery?
Eur Spine J
September 2025
Centre Hospitalier Universitaire de Tours, Tours, France.
Purpose: Degenerative lumbar spinal stenosis (DLSS) represents an increasing challenge due to the aging population. The natural course of untreated DLSS is largely unknown. For the acute DLSS decompensations, the main concern remains the opportunity and timing of surgery, i.
View Article and Find Full Text PDFComparative efficacy and safety of PSCA CAR-engineered Vδ1 γδ T cells for immunotherapy of pancreatic cancer.
J Immunother Cancer
September 2025
Division of Hematology & Oncology, Department of Medicine, School of Medicine, University of California, Irvine, California, USA
Background: γδ T cells possess unique immunological features including tissue tropism, major histocompatibility complex-independent antigen recognition, and hybrid T/natural killer cell properties that make them promising candidates for cancer immunotherapy. However, the therapeutic potential of Vδ1 γδ T cells, particularly when engineered with chimeric antigen receptors (CARs), remains underexplored in solid tumors such as pancreatic cancer (PC), largely due to their low abundance in peripheral blood and challenges in ex vivo expansion. This study aims to directly compare the preclinical safety and efficacy among CAR-engineered Vδ1 γδ T cells, Vδ2 γδ T cells, and conventional αβ T cells.
View Article and Find Full Text PDFThe Role of Generative Artificial Intelligence and Large Language Models in Atrial Fibrillation: Clinical Research and Decision Support.
Cardiol Rev
September 2025
Department of Medicine, New York Medical College, Valhalla, NY.
Atrial fibrillation (AF) is a prevalent and complex cardiac arrhythmia requiring multifaceted management strategies. This review explores the integration of large language models (LLMs) and machine learning into AF care, with a focus on clinical utility, privacy preservation, and ethical deployment. Federated and transfer learning methods have enabled high-performance predictive modeling across distributed datasets without compromising data security.
View Article and Find Full Text PDFPerfluoroalkyl substances exposure and kidney function decline in a community-based prospective cohort.
Ecotoxicol Environ Saf
September 2025
Department of Nephrology, Chang Gung Memorial Hospital, Keelung Branch, 222, Mai-Chin Road, Keelung 20401, Taiwan; College of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist, Taoyuan City, Taipei 33302, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital,
Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic chemicals widely used in industrial and consumer applications, known for their environmental persistence, bioaccumulation, and potential toxicity. Mounting toxicological evidence suggests that the kidney is a primary target organ for PFAS accumulation, yet human data regarding compound-specific renal effects remain limited. In this community-based prospective cohort study, we investigated the associations between serum PFAS concentrations and renal outcomes in 257 adults, including 48 with chronic kidney disease (CKD) and 209 with normal kidney function at baseline.
View Article and Find Full Text PDF