Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Vulvar and vaginal melanoma (VuM & VaM) is a rare gynecologic malignancy with high mortality but low effectiveness to checkpoint immunotherapy compared to cutaneous melanoma. This article aims to elucidate the role of the disordered immune microenvironment in cancer progression in VuM.
Methods: At first, this article applied single-cell RNA sequencing (scRNA-seq) to the VuM obtained from a 68-year-old female patient, and constructed a single-cell atlas of VuM consist of 12,243 single cells. Then this article explores the genomic complexity and core signal channel in VuM microenvironment.
Results: This article provides new insights about the pathogenesis of VuM based on single-cell resolution data. It was found that the activation of CD8 T cell contributed to induce tumor angiogenesis and immune escape, and the activation of the antigen-presenting molecular function participated in melanoma metastasis.
Conclusion: This article provided new insights into underlining VuM molecular regulation and potential signaling involved in immunotherapy, which would benefit the clinical practice and administration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10795381 | PMC |
| http://dx.doi.org/10.1186/s12885-024-11839-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
EVOLVE: A Web Platform for AI-Based Protein Mutation Prediction and Evolutionary Phase Exploration.
J Chem Inf Model
May 2025
Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, West Bengal 741246, India.
While predicting structure-function relationships from sequence data is fundamental in biophysical chemistry, identifying prospective single-point and collective mutation sites in proteins can help us stay ahead in understanding their potential effects on protein structure and function. Addressing the challenges of large sequence-space analysis, we present EVOLVE, a web tool enabling researchers to explore prospective mutation sites and their collective behavior. EVOLVE integrates a statistical mechanics-guided machine learning algorithms to predict probable mutational sites, with statistical mechanics calculating mutational entropy to accurately identify mutational hotspots.
View Article and Find Full Text PDFMitochondrial Sensitivity to Submaximal [ADP] Following Bed Rest: A Novel Two-Phase Approach Associated With Fibre Types.
J Cachexia Sarcopenia Muscle
June 2025
Department of Medicine, University of Udine, Udine, Italy.
Background: We recently demonstrated that following a 10-day exposure to inactivity/simulated microgravity impairments of oxidative metabolism were located 'upstream' of mitochondrial function, as evaluated by maximal ADP-stimulated mitochondrial respiration (JO) determined ex vivo. The aim of this study was to evaluate mitochondrial sensitivity to submaximal [ADP] by an alternative approach aimed at identifying responses associated with fibre type composition.
Methods: Isolated permeabilized vastus lateralis fibres were analysed by high-resolution respirometry in 9 young males before and after a 10-day horizontal bed rest.
Physiological and Biomechanical Responses Induced by a Continuous Test and an Intermittent Test in Middle-Distance Runners.
Int J Sports Physiol Perform
May 2025
Laboratory of Optimizing Research Programs on Physical and Sports Activities, Institute of Physical Education and Sports, University of Abdelhamid Ibn Badis of Mostaganem, Mostaganem, Algeria.
Purpose: This study aimed to examine middle-distance runners' acute physiological and biomechanical responses to 2 maximal aerobic speed tests: an intermittent test (5 × 1 mintest) and a continuous test (University of Montreal Track Test [UM-TT]).
Methods: Twenty trained male middle-distance runners completed the UM-TT and 5 × 1 mintest on separate days. The rating of perceived exertion, peak heart rate, and maximal aerobic speed of both tests (VUM-TT and V5 ×1m) were analyzed.
Previous short-term disuse dictates muscle gene expression and physiological adaptations to subsequent resistance exercise.
J Physiol
July 2025
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Short-term unloading experienced following injury or hospitalisation induces muscle atrophy and weakness. The effects of exercise following unloading have been scarcely investigated. We investigated the functional and molecular adaptations to a resistance training (RT) programme following short-term unloading.
View Article and Find Full Text PDFInitial Glutathione Depletion During Short-Term Bed Rest: Pinpointing Synthesis and Degradation Checkpoints in the γ-Glutamyl Cycle.
Antioxidants (Basel)
November 2024
Department of Medical Surgical and Health Sciences, ASUGI, University of Trieste, 34127 Trieste, Italy.
Hypokinesia triggers oxidative stress and accelerates the turnover of the glutathione system via the γ-glutamyl cycle. Our study aimed to identify the regulatory checkpoints controlling intracellular glutathione levels. We measured the intermediate substrates of the γ-glutamyl cycle in erythrocytes from 19 healthy young male volunteers before and during a 10-day experimental bed rest.
View Article and Find Full Text PDF