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An abundant literature reports on 'sequential effects' observed when humans make predictions on the basis of stochastic sequences of stimuli. Such sequential effects represent departures from an optimal, Bayesian process. A prominent explanation posits that humans are adapted to changing environments, and erroneously assume non-stationarity of the environment, even if the latter is static. As a result, their predictions fluctuate over time. We propose a different explanation in which sub-optimal and fluctuating predictions result from cognitive constraints (or costs), under which humans however behave rationally. We devise a framework of costly inference, in which we develop two classes of models that differ by the nature of the constraints at play: in one case the precision of beliefs comes at a cost, resulting in an exponential forgetting of past observations, while in the other beliefs with high predictive power are favored. To compare model predictions to human behavior, we carry out a prediction task that uses binary random stimuli, with probabilities ranging from 0.05 to 0.95. Although in this task the environment is static and the Bayesian belief converges, subjects' predictions fluctuate and are biased toward the recent stimulus history. Both classes of models capture this 'attractive effect', but they depart in their characterization of higher-order effects. Only the precision-cost model reproduces a 'repulsive effect', observed in the data, in which predictions are biased away from stimuli presented in more distant trials. Our experimental results reveal systematic modulations in sequential effects, which our theoretical approach accounts for in terms of rationality under cognitive constraints.
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http://dx.doi.org/10.7554/eLife.81256 | DOI Listing |
Inorg Chem
September 2025
Yunnan Key Laboratory of Crystalline Porous Organic Functional Materials, College of Chemical and Materials Engineering, Qujing Normal University, Qujing 655011, China.
Sequential assembly of donor-acceptor components at the molecular level within a MOF is an effective strategy to achieve efficient electron-hole separation for enhancing the activity of photocatalysts. Meanwhile, the highly efficient and selective functionalization of tetrahydroisoquinoline (THIQ) under mild conditions remains an urgent demand in both the scientific and industrial communities. This work reports a donor-acceptor MOF photocatalyst () constructed by the coordinated assembly of donor and acceptor components, in which a naphthalene unit serves as an electron donor and a perylenediimide unit as an electron acceptor.
View Article and Find Full Text PDFDermatology
September 2025
Department of Clinical Pharmacology and Toxicology, University of Geneva, Geneva, Switzerland.
Background: Maintaining homeostasis in the upper pilosebaceous unit in acne-prone skin has emerged as the primary goal for effective and long-term acne management.
Summary: In this review, we describe advances in acne research that have helped redefine the strategic targets for new topical acne treatments, providing the basis for new therapeutic strategies that may allow this goal to be achieved.
Key Messages: First, we describe the results of studies analyzing apparently uninvolved skin from individuals with acne, using sequential skin surface biopsies.
Physiother Theory Pract
September 2025
Clinical Vestibulology Observer, Otoneurology Centre, Udaipur, India.
Background: Multi-canal benign paroxysmal positional vertigo (MC-BPPV) is a rare form of BPPV characterized by the simultaneous involvement of multiple semicircular canals, often resulting in complex diagnostic and therapeutic challenges. While MC-BPPV most commonly affects the posterior and horizontal semicircular canals, tri-canal involvement - especially with bilateral asymmetry - is exceedingly rare.
Purpose: To describe a unique case of tri-canal BPPV involving right posterior and horizontal semicircular cupulolithiasis and left horizontal semicircular canalolithiasis, successfully managed with a structured, sequential protocol of repositioning maneuvers including a novel Bascule maneuver.
Eur J Nucl Med Mol Imaging
September 2025
Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Purpose: Cardiac noradrenergic denervation visualized by meta-[I]iodobenzylguanidine ([I]MIBG) imaging supports the diagnosis of Parkinson's disease (PD). Recently, meta-[F] fluorobenzylguanidine ([F]MFBG) PET demonstrated favorable imaging characteristics compared with [I]MIBG scintigraphy for neuroendocrine tumors. We assessed [F]MFBG dosimetry and myocardial pharmacokinetics in healthy controls and PD patients.
View Article and Find Full Text PDFSyst Biol
September 2025
Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY 10027, USA.
Genomes are composed of a mosaic of segments inherited from different ancestors, each separated by past recombination events. Consequently, genealogical relationships among multiple genomes vary spatially across different genomic regions. Genealogical variation among unlinked (uncorrelated) genomic regions is well described for either a single population (coalescent) or multiple structured populations (multispecies coalescent).
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