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Article Abstract
Somatic versus Germline-A Case Series of Three Children with ATM- mutated Medulloblastoma.
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| http://dx.doi.org/10.1200/PO.23.00333 | DOI Listing |
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Laparoscopic resection has become the standard surgical technique in treating colorectal cancer. This approach has many advantages over open surgery such as: faster recovery, lower postoperative pain with reduced postoperative pain scores and opioid requirements and shorter hospital-stay. Improving postoperative pain management by performing transversus abdominis plane block enhances some of the benefits of laparoscopic colorecat surgery.
View Article and Find Full Text PDFHomologous recombination deficiency and survival in ovarian high-grade serous carcinoma by self-reported race.
Cancer Epidemiol Biomarkers Prev
September 2025
Emory University, Atlanta, GA, United States.
Background: Half of ovarian high-grade serous carcinomas (HGSC) have homologous recombination deficiency (HRD). However, HRD is not well-characterized in Black individuals who experience worse survival after a diagnosis of HGSC. The objective of this study was to characterize ovarian HGSC HRD and examine its association with survival by self-reported race.
View Article and Find Full Text PDFImpact of ASXL1 at diagnosis in patients with CML receiving frontline potent TKIs: high risk of kinase domain mutations.
Blood
September 2025
Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
Genomic profiling in chronic-phase chronic myeloid leukemia (CP-CML) patients demonstrated somatic variants in blood cancer-related genes (CGVs) and rearrangements associated with the formation of the Philadelphia-chromosome (Ph-associated rearrangements) at diagnosis, collectively termed additional genetic abnormalities (AGA). AGAs had a negative impact on failure-free survival and molecular response in imatinib-treated patients. We investigated whether treatment with more potent therapies could overcome the negative impact of AGAs at diagnosis.
View Article and Find Full Text PDFObjective: This randomized cross-over trial aimed to compare the effects of a one-session emotion-focused intervention, the Life Stress Interview (LSI), with a Basic Assessment of psychiatric Symptoms (BAS) condition for patients with Persistent Physical Symptoms (PPS).
Methods: One-hundred and eighty-nine participants (n=189), predominantly middle-aged females with high psychiatric comorbidity and persistent somatic symptoms, were randomly assigned to receive both LSI and BAS in varying order. Symptom change over time and interaction effects were analyzed using linear mixed models.
The association between respiratory physiology and self-reported respiratory symptoms in patients with persistent somatic symptoms.
J Psychosom Res
August 2025
Department of Clinical Neurosciences, Wrocław University of Science and Technology, Poland.
Background: Persistent somatic symptoms (PSS) comprise a spectrum of physical complaints arising from complex interactions between various biomedical and psychosocial factors. This study aimed to investigate both physiological and self-reported respiratory measures in individuals with PSS compared to healthy controls, and examine factors associated with dyspnea and functional respiratory complaints in patients with PSS.
Materials/methods: 38 patients meeting DSM-5 criteria for Somatic Symptom Disorder and 38 matched healthy controls completed respiratory assessments, including spirometry, capnography (etCO₂), and manual evaluation of thoracic versus diaphragmatic breathing patterns.