Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Study advisory committees (SACs) provide critical value to clinical trials by providing unique perspectives that pull from personal and professional experiences related to the trial's healthcare topic. The Emergency Medicine Palliative Care Access (EMPallA) study had the privilege of convening a 16-person SAC from the project's inception to completion. The study team wanted to understand the impact this project had on the SAC members. In this narrative, we use reflective dialogue to share SAC members' lived experiences and the impact the EMPallA study has had on members both personally and professionally. We detail the (1) benefits SAC members, specifically patients, and caregivers, have had through working on this project. (2) The importance of recruiting diverse SAC members with different lived experiences and leveraging their feedback in clinical research. (3) Value of community capacity building to ensure the common vision of the clinical trial is promoted.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768616PMC
http://dx.doi.org/10.1177/23743735231224562DOI Listing

Publication Analysis

Top Keywords

sac members
12
study advisory
8
palliative care
8
empalla study
8
lived experiences
8
study
5
members
5
sac
5
what's you?
4
you? what's
4

Similar Publications

Background: The earthworm fauna of India remains inadequately documented, despite its pivotal ecological importance, and there is a pressing need to address this gap. Recognizing this lack of comprehensive documentation, the present study was undertaken to explore and characterize the diversity in previously under-surveyed regions. During systematic surveys in Madhya Pradesh (Central India) and Manipur (North-Eastern India), four novel species of the genus Drawida Michaelsen, 1900 were discovered: D.

View Article and Find Full Text PDF

An inducible model of human post-implantation development derived from primed and naive stem cells.

Cell Stem Cell

August 2025

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texa

Early post-implantation human development is poorly understood due to limited access to natural embryos. Integrated stem cell-based embryo models (SCBEMs) offer an alternative, but current models face challenges in reproducibility, efficiency, and genomic stability. Here, we developed inducible SCBEMs (iSCBEMs) by combining primed human pluripotent stem cells (hPSCs) with transgene-induced extraembryonic cells derived from naive hPSCs.

View Article and Find Full Text PDF

Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia.

Mol Neurodegener

August 2025

Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, The Netherlands.

Background: Diagnosis of Frontotemporal dementia (FTD) and its specific underlying neuropathologies (frontotemporal lobar degeneration; FTLD-Tau and FTLD-TDP) are challenging, and thus, fluid biomarkers are needed to improve diagnostic accuracy.

Methods: We used proximity extension assays to analyze 665 proteins in cerebrospinal fluid (CSF) samples from a multicenter cohort, which included patients with FTD ( = 189), Alzheimer’s Disease dementia (AD;  = 232), and cognitively unimpaired individuals ( = 196). In a subset, FTLD neuropathology was determined based on phenotype or genotype (FTLD-Tau = 87 and FTLD-TDP = 67).

View Article and Find Full Text PDF

From Diagnosis to Discharge: Case of a Giant Occipital Encephalocele.

Neonatal Netw

August 2025

Department of Advanced Practice Nursing Practice & Education, East Carolina University, College of Nursing, Greenville, NC, USA.

Occipital encephalocele, a rare and unique congenital brain malformation, occurs when a portion of the brain and/or cerebrospinal fluid (CSF) protrudes through a defect in the bony structure of the skull. This herniation of CSF and brain tissue is usually contained within a skin-covered sac. When an occipital encephalocele measures larger than the circumference of the head, it is classified as a giant occipital encephalocele.

View Article and Find Full Text PDF