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http://dx.doi.org/10.1186/s13024-023-00681-w | DOI Listing |
Biomater Sci
September 2025
School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.
The increasing use of blood-contacting medical devices has brought about significant advancements in patient care, yet it also presents challenges such as thrombus formation and infection risks. Surface coatings play a vital role in mitigating these side effects, enhancing the safety and effectiveness of such devices. In this study, we introduced a novel coating employing poly(aspartic acid) (PASP), which can be easily applied through various modification pathways.
View Article and Find Full Text PDFJ Pediatr Hematol Oncol
September 2025
Children's Hospital of Michigan, Division of Hematology/Oncology.
Glanzmann thrombasthenia (GT) is a rare autosomal recessive platelet disorder characterized by abnormalities in platelet aggregation, resulting from quantitative or qualitative defects in integrins αIIb and β3. Currently, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only potentially curative therapeutic approach for severe GT. In this report, we present 2 children with GT that underwent successful allo-HSCT, along with 2008 to 2022 data from the Center for International Blood and Marrow Transplant Research and a summary of the existing literature providing further evidence that allo-HSCT can be a curative approach that prevents severe and life-threatening bleeding in GT.
View Article and Find Full Text PDFJ Clin Lab Anal
September 2025
Department of Nursing, National Tainan Junior College of Nursing, Tainan, Taiwan.
Background: Improving efficiency and reducing turnaround time are crucial in clinical laboratories. While automated analyzers such as the Beckman Coulter DxH 900 streamline workflow, subtle abnormalities like blasts and immature granulocytes (IGs) may be missed, especially in the absence of WBC-related suspect messages. This study evaluated whether integrating cell population data (CPD) with instrument messages could enhance detection accuracy.
View Article and Find Full Text PDFEur J Case Rep Intern Med
August 2025
Department of Internal Medicine, University Hospital of Basel, Basel, Switzerland.
Unlabelled: Piperacillin/tazobactam (PTZ) is known to cause cytopenia but case reports on PTZ causing combined haemolytic anaemia and thrombocytopenia are scarce. We report on a 56-year-old male who developed severe, immune-mediated thrombocytopenia and anaemia during two treatment episodes with PTZ. After the first exposure, his blood count rapidly returned to normal after discontinuation of PTZ.
View Article and Find Full Text PDFCrit Care Explor
September 2025
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Objective: Vitamin C has been linked to alterations in platelet count and aggregation behavior. Given recent findings suggesting an association between vitamin C and adverse outcomes in patients with septic shock, we aimed to investigate whether vitamin C influences mortality in septic patients through its impact on platelets.
Design: Post hoc analysis of the Lessening Organ Dysfunction With Vitamin C (LOVIT) randomized trial (clinicaltrials.